IMRT联合TP方案治疗局部晚期食管鳞癌疗效及安全性研究  

Clinical Efficacy and Safety of Intensity Modulated Radiotherapy Combined with TP Chemotherapy for Local Advanced Esophagus Squamous Cell Carcinoma

作　　者：许俐文 丁婷[1] 姚晓丹[1] 王纯 XU Liwen, DING Ting, YAO Xiaodan, et al.(Wuhan Central Hospital, Tongji Medical Colloge, Huazhong University of Science and Technology, Wuhan , 43001)

机构地区：[1]华中科技大学同济医学院附属武汉中心医院,430014

出　　处：《实用癌症杂志》2018年第4期602-605,共4页The Practical Journal of Cancer

摘　　要：目的研究调强放疗(intensity modulated radiotherapy,IMRT)联合TP方案治疗局部晚期食管鳞癌疗效及安全性研究。方法根据患者治疗方式分为观察组(IMRT联合TP方案治疗)和对照组(单纯TP方案治疗),比较两组患者疗效、毒性不良反应和生存质量的差异。结果观察组患者中治疗总有效率和CR率明显高于对照组(P<0.05);治疗后的生存质量Karnofsky评分观察组高于对照组,差异具有统计学差异,(P<0.05);同时观察组不良反应与术后并发症发生率方面,两组比较差异均无统计学意义。结论 IMRT联合TP方案治疗局部晚期食管鳞癌可显著提高患者疗效和生存质量,但不增加并发症及毒性不良反应。Objective To evaluate the efficacy and safety of intensity modulated radiotherapy（IMRT） combined with TP chemotherapy for local advanced esophagus squamons cell carcinoma. Methods 76 patients with advanced esophagus squamous cell carcinoma were randomly divided into the observation group and the control group. Each group with 38 cases. The observation group was treated with IMRT combined with TP chemotherapy, the control group received only TP regimen chemotherapy, clinical efficacy and safety of the 2 groups were compared. Results The total effective rate and CR rate in the observation group were sig- nificantly higher than those of the control group （ P 〈 0.05 ）. The Karnofsky score of the observation group was significantly higher than that of the control group, the difference was statistically significant （ P 〈 0.05 ） ; There was no significant difference between the 2 groups in the incidence of adverse reactions and postoperative complications. Conclusion IMRT combined with TP regimen can improve the clinical curative effect for local advanced esophagus squamous cell carcinoma and quality of life, without increase the side effects.

关 键 词：IMRT TP方案 局部晚期食管癌 

分 类 号：R735.1[医药卫生—肿瘤]