锌剂治疗复发性口腔溃疡疗效的Meta分析  

The efficacy of zinc medicine in the treatment of recurrent aphthous ulcers: A Meta analysis

作　　者：党如意 田国才 陈玲 DANG Ruyi1, TIAN Guocai1, CHEN Ling2(1. 400331, School of Stomatology, 2. Experimental Teaching Cen- ter, Chongqing Medical University, Chin)

机构地区：[1]重庆医科大学口腔医学院,400016 [2]重庆医科大学实验教学管理中心

出　　处：《实用口腔医学杂志》2018年第2期230-233,共4页Journal of Practical Stomatology

摘　　要：目的:评价使用锌剂治疗复发性口腔溃疡(RAU)的疗效。方法:计算机检索1980-01-01~2016-06-01间Pubmed、CENTRAL、EMbase、中国知网、万方数据库中关于锌剂治疗RAU的随机对照实验(RCTs),同时手动筛检纳入文献的参考文献。对文献质量进行严格评价和资料提取,并用Stata软件进行Meta分析。结果:纳入的4个RCTs共156例患者,其中使用锌剂治疗74例,安慰剂对照组82例。结果显示锌剂对RAU有良好的治疗作用(P<0.05)。结论:应用锌剂治疗RAU安全有效。机体缺锌是复发性口腔溃疡的一个危险因素。Objective： To evaluate the curative effects of zinc medicine in the treatment of recurrent aphthous ulcers （RAU）. Methods. The randomized controlled trials （RCTs） about the zinc medicine in the treatment of RAU were retrieved from PubMed, CENTRAL, EMbase, CNKI and WANFANG from January 1, 1980 to June 1,2016, the references included in the study were man- ually selected. After quality evaluation and material extraction by the reviewer, Meta analysis was done according to the documents and materials by software Stata. Results： 4 RCTs involving 156 patients were included in the study, with 74 cases in the zinc medi- cine treatment group and 82 cases in the placebo control group. Meta analysis showed that zinc medicine was effective in the treat- ment of RAU （P 〈 0.05 ）. Conclusion： Zinc medicine is safe and effective in the treatment of RAU. Zinc deficiency is a risk factor

关 键 词：复发性口腔溃疡(RAU) 锌 系统评价 META分析 随机对照实验 

分 类 号：R781.5[医药卫生—口腔医学]