原发性胃淋巴瘤的临床病理特点及预后影响因素  

Clinical characteristics and prognostic factors of primary gastric lymphoma

作　　者：翟敏[1] 张海涛[1] 王运良[1] 王飞[1] 周小刚 支巧明[1] 周进[1] Zhai Min, Zhang Haitao, Wang Yunliang, Wang Fei, Zhou Xiaogang, Zhi Qiaoming, Zhou Jin.(Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215000, Chin)

机构地区：[1]苏州大学附属第一医院普外科,江苏省215000

出　　处：《中华普通外科杂志》2018年第3期232-234,共3页Chinese Journal of General Surgery

基　　金：国家自然科学基金资助项目（81302148）;中国博士后科研基金面上资助项目（13KJB320019）;江苏省博士后科研基金资助项目（1601186B）;江苏省研究生培养创新工程资助项目（ZY32005416）

摘　　要：目的探讨原发性胃淋巴瘤的临床病理特点及预后影响因素。方法回顾性分析2012年9月至2017年1月间苏州大学附属第一医院收治的78例原发性胃淋巴瘤患者的临床资料。结果78例原发性胃淋巴瘤患者的1年和3年生存率分别为86％和68％。单因素分析结果表明：血清乳酸脱氢酶水平（χ^2=35．088，P=0．000）、Musshoff分期（χ^2=29．930，P=0．000）、病理类型（χ^2=6．077，P=0．014）、IPI评分（χ^2=21．337，P=0．000）是影响预后的相关因素。多因素分析结果表明：Musshoff分期是影响预后的独立因素，Ⅲ期（OR=11．994，95％CI：1．042-138．083，P=0．046）和Ⅳ期（OR=13．165，95％CI：1．476-117．417，P=0．021）患者的生存率比I期患者低。结论Musshoff分期是影响原发性胃淋巴瘤患者预后的独立因素，外科手术治疗并不能有效延长患者的生存期，目前仍以化疗为首选治疗方式。Objective To explore the clinical characteristics and prognostic factors of primary gastric lymphoma. Methods Clinical data of 78 primary gastric lymphoma patients treated between September 2012 and January 2017 in our hospital were analyzed retrospectively. Results 1-year and 3-year survival rate were 86% and 68% respectively. Univariate analysis showed that the four factors including the level of serum lactate dehydrogenase （χ^2 = 35. 088, P = 0. 000 ） , Musshoff stage （χ^2 = 29. 930, P = 0. 000） , pathology types （χ^2 = 6. 077, P = 0. 014） , IPI score （X2 = 21. 337, P = 0. 000） were associated with the prognosis. Multivariate analysis showed that Musshoff stage was an independent risk factor for the prognosis when stage I , stage 11 （ OR = 1. 075, 95% CI：0. 060 - 19. 107, P = 0. 961 ） were compared with stage UI （ OR = 11. 994, 95% CI： 1. 042 - 138. 083, P = 0. 046） , or stage IV （ OR = 13. 165, 95% CI：1. 476 - 117. 417, P = 0. 021 ）. Conclusions Musshoff stage is an independent factor for the prognosis, surgical treatment can not prolong survival and chemotherapy is the therapy of choice.

关 键 词：淋巴瘤 病理学 临床 预后 

分 类 号：R735.2[医药卫生—肿瘤]