Bcl-2与肿瘤转移的研究进展  

Progress in the study of Bcl-2 and tumor metastasis

作　　者：刘蕾[1] 李砚 王莎莎[3] LIU Lei;LI Yan;WANG Shasha(Research Center of Experimental Medicine, the Third People＇s Hospital of Chengdu Second Affiliated Hospital, Chongqing Medical University, Sichuan Province, Chengdu 610031, China;Department of Infectious Diseases, No. 42 Hospital of PLA, Sichuan Province, Leshan 614000, China;Department of Biotechnology, Chengdu Medical Col- lege, Sichuan Province, Chengdu 610083, China)

机构地区：[1]成都市第三人民医院重庆医科大学附属成都第二临床学院实验医学研究部,四川成都610031 [2]解放军第四十二医院感染科,四川乐山614000 [3]成都医学院生物技术系,四川成都610083

出　　处：《中国医药导报》2018年第7期40-43,共4页China Medical Herald

基　　金：国家自然科学青年基金项目(81402013);四川省科技厅应用基础研究面上项目(2017JY0094);四川省医学会青年创新课题(Q16006);四川省卫生和计生委普及应用项目(17PJ484)

摘　　要：转移是恶性肿瘤最主要的生物学特性之一,是危及患者生命的主要原因。Bcl-2分子一直以来被认为是抗凋亡的关键因子,但近期研究表明Bcl-2分子在促进肿瘤转移中也发挥重要作用。本文从细胞水平、动物模型和临床样本三个方面,针对Bcl-2分子在调节细胞迁移、侵袭和肿瘤转移中的作用及相关分子机制进行论述,并对以Bcl-2分子为靶标的治疗策略进行展望,期望为抑制肿瘤转移提供依据。Metastasis is one of the most important biological characteristics of malignant tumor, and it is the main risk factor to the patient/s life. Bcl-2 is considered as a key factor in anti-apoptosis, but recent studies show that Bcl-2 may play an important role in promoting tumor metastasis. In this paper, review the function of bcl-2 in regulating cell migration, invasion and tumor metastasis and discuss associated molecular mechanism in cellular, animal models and patients levels, and also make a prospect for the therapeutic strategy to target Bcl-2, in order to provide a basis for the inhibition of tumor metastasis.

关 键 词：BCL-2 肿瘤转移 MICRO RNA 

分 类 号：R736.1[医药卫生—肿瘤]