祛脂方联合西药治疗非酒精性脂肪肝随机平行对照研究  

Randomized Controlled Study on the Treatment of Nonalcoholic Fatty Liver with the Prescription of Removing Fat and Western Medicine

作　　者：龚文涵 GONG Wenhan(Department of Infection management of Nanyang First People＇s Hospital,Nanyang 473000,Henan,Chin)

机构地区：[1]南阳市第一人民医院感染管理科,河南南阳473000

出　　处：《实用中医内科杂志》2018年第2期35-37,共3页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察祛脂方联合西药治疗非酒精性脂肪肝疗效。[方法]使用随机平行对照方法,将86例住院患者按病志号抽签随机分两组。对照组43例硫普罗宁0.2g+5%葡萄糖250m L,静滴,1次/d;维生素B,2片/次,3次/d。治疗组43例祛脂方(丹参、生黄芪各30g,决明子20g,制何首乌、泽泻、枸杞子、生白术各15g,五味子12g,生蒲黄、制大黄各10g),1剂/d,水煎200m L,早晚口服;硫普罗宁治疗同对照组。连续治疗30d为1疗程。观测临床症状、甘油三酯(TG)、总胆固醇(TCH)、高密度脂蛋白(HDL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效26例,有效14例,无效3例,总有效率93.02%;对照组显效17例,有效15例,无效11例,总有效率74.41%;治疗组疗效优于对照组(P<0.05)。TG、TCH、HDL、ALT、AST两组均有改善(P<0.05,P<0.01),治疗组优于对照组(P<0.05,P<0.01)。[结论]祛脂方联合西药治疗非酒精性脂肪肝,疗效满意,无严重不良反应,值得推广。[Objective] To observe the curative effect of removing fat prescription combined with western medicine in the treatment of nonalcoholic fatty liver. [Methods] 86 cases of hospitalized patients were randomly divided into two groups by random parallel control. In the control group, 43 cases of tiopronin 0.2g＋5% glucose 250mL, intravenous drip, 1 times/d, vitamin B, 2 tablets/times, and 3 times/d. The treatment group of 43 cases of Quzhi decoction （radix salviae mihiorrhizae, radix astragali 30g, cassia 20g, radix polygoni multiflori preparata, rhizoma alismatis, medlar, white atractylodes rhizome 15g, schisandra 12g, rhubarb 10g, pollen Typhae）, 1 agent/d, 200mL oral decoction, sooner or later; tiopronin treatment with the control group. The continuous treatment of 30d was 1 courses. Observation of clinical symptoms, serum triglyceride （TG）, total cholesterol （TCH）, high density lipoprotein （HDL）, alanine aminotransferase （ALT） and aspartate aminotransferase （AST）, adverse reaction. The 1 course of treatment was treated and the curative effect was determined. [Results] The treatment group was markedly effective in 26 cases, effective in 14 cases, invalid in 3 cases, the total effective rate was 93.02%. In the control group, 17 cases were markedly effective, 15 eases were effective, 11 cases were invalid, the total effective rate was 74.41%, the treatment group was better than the control group （P〈0.05）. The two groups of TG, TCH, HDL, ALT and AST were improved （P 〈0.05, P〈0.01）. The treatment group was superior to the control group （P〈0.05, P〈0.01）. [Conclusion] the effect of removing fat and western medicine on non-alcoholic fatty liver is satisfactory, and there is no serious adverse reaction. It is worth popularizing.

关 键 词：非酒精性脂肪肝 祛脂方 硫普罗宁 维生素B 甘油三酯(TG) 总胆固醇(TCH) 高密度脂蛋白(HDL) 谷丙转氨酶(ALT) 谷草转氨酶(AST) 中西医结合治疗 中药复方 随机平行对照研究 

分 类 号：R575.5[医药卫生—消化系统]