依替巴肽合成路线图解  

Synthetic Routes of Eptifibatide

作　　者：赵跃[1] 王菊仙[1] 王玉成[1] ZHA O Yue;WANG Ju-xian;WANG Yu-cheng(Institute of Medicinal Biotechnology Chinese Academy of Medical Science ＆ Perking Union medical College, Beijing 100050,China)

机构地区：[1]中国医学科学院北京协和医学院医药生物技术研究所,北京100050

出　　处：《精细化工中间体》2017年第5期9-14,18,共7页Fine Chemical Intermediates

摘　　要：通过对现有的依替巴肽合成方法的分析,针对不同的合成工艺提出适合工业化生产的路线。以Fmoc保护的氨基酸作为起始原料通过液相合成法,其中通过将赖氨酸转换为高精氨酸,有效地降低了成本,工艺合成灵活,条件温和,具有工业化应用前景。Based on the review of the existing methods for the preparation of eptifibatide, a suitable route for industrial production was proposed for different synthetic processes. In this process, Fmoc protected amino acids was the starting material; lysine was converted to arginine; the cost was effectively reduced; this synthetic route is flexible, mild conditions, suitable for industrial production of eptifibatide.

关 键 词：依替巴肽 固相合成 液相合成 合成路线图解 

分 类 号：R914[医药卫生—药物化学]