芙蓉菊化学成分及其生物活性研究进展  

Advances in studies on active components and their biological activities in Crossostephium chinense

作　　者：吴琦[1] 王亚君 赵琳 杨秀伟[3,4] 马爱进[1] WU Qi1, WANG Ya-jun2, ZHAO Lin1, YANG Xiu-wei3,4, MA ai-jin1(1. China National Institute of Standardization, Beijing 100191, China 2. Xiamen Institute for Food and Drug Quality Control, Xiamen 361012, China 3. State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, Peking University, Beijing 100191, China 4. School of Pharmaceutical Sciences, Peking University, Beijing 100191, Chin)

机构地区：[1]中国标准化研究院食品与农业标准化研究所,北京100191 [2]厦门市食品药品质量检验研究院,福建厦门361012 [3]北京大学天然药物及仿生药物国家重点实验室,北京100191 [4]北京大学药学院天然药物学系,北京100191

出　　处：《药物评价研究》2017年第12期1821-1827,共7页Drug Evaluation Research

基　　金：国家重点研发计划(2016YFF0202300)

摘　　要：芙蓉菊Crossostephium chinense为菊科蕲艾属植物,主要分布在我国东南部地区及东南亚各国。芙蓉菊叶入药有袪风湿、消肿毒的作用;根入药治疗风湿关节痛和胃脘冷痛;广东民间用其治疗糖尿病,效果良好。现代研究显示芙蓉菊中含有挥发油、黄酮类、倍半萜类、三萜类、香豆素类、多糖等化学成分;其提取物或单体具有抗糖尿病、抗氧化、镇痛消炎、保肝、抗增殖等生物活性,在治疗糖尿病等方面具有潜在开发前景。Crossostephium chinense is a plant of the genus Crossostephium Less in the family Asteraceae. It widely distributes in the coast area of the southeastern part of China, and Southeast Asian countries. The leaves of Crossostephium chinense used as medicine have the effect of dispelling wind and dampness, and dispersing swelling and toxin. The roots of Crossostephium chinense can be used to treat rheumatoid arthritis and cold pain in stomach duct. Folk people in Guangdong have described its usage for the treatment of diabetes mellitus with good effect. Modern researches reveal that it contains chemical constituents like volatile oils, flavonoids, sesquiterpenes, triterpenes, coumarins, and polysaccharides, and its chemical constituents have various biological activities in antidiabetes, antioxidation, anti-inflammation, liver-protecting, and anti-proliferation. These results provide some insights for its further research and development in the treatment of diabetes.

关 键 词：芙蓉菊 三萜 黄酮 生物活性 抗糖尿病 

分 类 号：R286[医药卫生—中药学]