肿瘤坏死因子α诱导蛋白8家族的研究进展  

Research progress of tumor necrosis factor-a induced protein 8 family

作　　者：翟敏[1] 满忠松 朱中伟 周进[1] 张海涛[1] Zhai Min, Man Zhongsong, Zhu Zhongwei, Zhou Jin, Zhang Haitao(Department of General Surgery, the First Affiliated Hospital of Soochow University, Jiangsu Suzhou 215000, Chin)

机构地区：[1]苏州大学附属第一医院普外科,215000

出　　处：《中国医师进修杂志》2017年第10期954-957,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：肿瘤坏死因子α诱导蛋白8（tumor necrosis factor-αinduced protein 8,TNFAIP8）是新近发现的由肿瘤坏死因子（TNF）-α诱导产生的一组蛋白.该蛋白家族拥有四个高度同源性的成员：TIPE（TNFAIP8）、TIPE1（TNFAIP8L1）、TIPE2（TNFAIP8L2）、TIPE3（TNFAIP8L3）.随着研究的不断深入,我们发现TNFAIP8家族在细胞凋亡、信号转导、肿瘤细胞增生、侵袭及转移等过程中起着重要的调节作用.本文综述了TNFAIP8蛋白家族的结构、机制、生物学功能的研究进展.Tumor necrosis factor-a induced protein 8 family is a group of newly discovered proteins induced by tumor necrosis factor-a. This protein family owns four highly homologous members： TIPE, TIPE 1, TIPE2, TIPE3. With the deepening of the research, we found that TNFAIP8 family plays an important role in cell apoptosis, signal transduction, invasion and metastasis of tumor cell proliferation. This paper reviews the structure, mechanism, and biological function of the TNFAIP8 family.

关 键 词：肿瘤坏死因子Α 生物学 综述 诱导蛋白8 

分 类 号：R730.2[医药卫生—肿瘤]