和胃化湿汤联合四联疗法治疗幽门螺杆菌相关消化性溃疡的疗效分析  

Effect of stomach dampness decoction combed with quadruple therapy in the treatment of Hp related peptic ulcer

作　　者：刘加新[1] 柳冬兵[1] 徐甦[1] 仇冬则[1] Liu Jiaxin,Liu Dongbing,Xu Su, Qiu Dongze.(Department of Gastroenterology, the Traditional Chinese Medicine Hospital of Huzhou, Huzhou, Zhejiang 313000, China)

机构地区：[1]湖州市中医院消化内科,浙江省湖州313000

出　　处：《中国基层医药》2018年第6期696-700,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省湖州市科技计划项目（2013GY12）

摘　　要：目的观察和胃化湿汤联合四联疗法治疗幽门螺杆菌（Hp）相关消化性溃疡的疗效。方法采用区组随机化法将80例Hp相关消化性溃疡患者分为两组各40例。对照组采用四联疗法（口服泮托拉唑肠溶片、枸橼酸铋钾颗粒、阿莫西林胶囊、左氧氟沙星片），研究组在对照组基础上加服和胃化湿汤，疗程为14d，1个月后评估，观察溃疡愈合情况及临床症状改善情况。结果研究组溃疡愈合质量中溃疡治愈率（82．5％）高于对照组（62．5％）（Х^2=4．013，P=0．045），而两组总有效率（95．0％比87．5％）差异无统计学意义（Х^2=0．626，P=0．429）；两组治疗前各项伴随症状积分及总积分差异均无统计学意义（均P〉0．05）；治疗后研究组各项伴随症状积分及总积分均有所减低，且饱胀[（0．28±1．03）分比（0．62±0．87）分，Z=-2．022]、嗳气[（0．40±0．67）分比（0．88±1．04）分，Z=-2．054]、嘈杂[（0．25±0．49）分比（0．60±0．78）分，Z=-2．135]、腹泻[（0．25±0，49）分比（0．62±0．71）分，Z=-2．642]及总积分[（2．52±1．71）分比（4．35±2．76）分，Z=-3．073]优于对照组，差异均有统计学意义（均P〈0．05）。研究组伴随症状总有效率（97．5％）高于对照组（75．O％）（x。=6．746，P=0．009）。结论和胃化湿汤联合四联疗法治疗Hp相关消化性溃疡的临床疗效显著，可有效提高治愈质量。Objective To observe the effect of stomach dampness decoction combed with quadruple therapy in the treatment of Hp related peptic ulcer. Methods 80 patients with Hp related peptic ulcer were randomly divided into two groups according to randomized block design, with 40 cases in each group. The control group received the quadruple therapy, inculding orally pantoprazole enteric -coated tablets, bismuth potassium citrate granules, amoxicillin capsules, levofloxacin tablets. The study group was given Hewei Huashi decoction on the basis of the control group. The duration of treatment was 14 days and the effect was assessed after 1 month, the healing of ulcer and the improvement of clinical symptoms were observed. Results The ulcer healing rate in the study group （82.5%） was higher than that in the control group （62.5%）, the difference was statistically significant（ Х^2 = 4. 013, P = 0. 045 ）. There was no statistically significant difference in total effective rate between the two groups （95.0% vs. 87.5% ,Х^2 = 0. 626,P = 0. 429 ）. Before treatment, there were no statistically significant differences in the integral and the total integral of the imuhaneous phenomenon between the two groups（ all P 〉 0.05 ）. After treatment, the accompanying symptom scores and the total integral of the study group significantly reduced, and the fullness[ （0.28 ± 1.03 ）points vs. （0.62 ± 0.87 ） points, Z = - 2. 022 ], ructus [ （ 0.40 ± 0.67 ） points vs. （0.88 ± 1.04 ） points, Z = - 2. 054 ], noisy [ （0.25 ± 0.49 ） points vs. （ 0.60 ± 0.78 ） points, Z = - 2. 135 ], diarrhea [ （ 0.25 ± 0.49 ） points vs. （ 0.62 - 0.71 ） points,Z = - 2. 642 ] and the total score [ （ 2.52 ± 1.71 ） points vs. （ 4.35 ± 2.76 ） points, Z = - 3. 073 ] were better than those of the control group, and the differences were statistically significant （ all P 〈 0.05 ）. The total effective rate of imultaneous phenomenon in the study group（97, 5% ） was higher than that of the control group

关 键 词：消化性溃疡 螺杆菌 幽门 药物疗法 联合 和胃化湿汤 

分 类 号：R573.1[医药卫生—消化系统]