乳腺癌患者血清白细胞介素-1β、白细胞介素-8、基质蛋白酶-2／9的表达及临床意义  

Clinical significanc of IL - 1β, IL - 8 and MMP - 2/9 in patients with breast cancer

作　　者：邢汉飞[1] 闫辉 纪秀猛 宋淑玲[1] 周宁 Xing Hanfei, Yan Hui, Ji Xiumeng,Song Shuling,Zhou Ning.(Department of Thyroid Breast Surgery, Binzhou Central Hospital, Binzhou, Shandong 251700, China)

机构地区：[1]滨州市中心医院甲状腺乳腺外科,山东省滨州251700

出　　处：《中国基层医药》2018年第6期756-759,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的通过检NSL腺癌患者中白细胞介素-1β（IL-1β）、白细胞介素-8（IL-8）和基质蛋白酶-2／9（MMP-2／9）的表达水平，探讨乳腺癌发生发展与IL-1β、IL-8和MMP-2／9的关系及其临床意义。方法选择乳腺癌患者60例（A组），乳腺增生患者30例（B组），健康体检者30例（C组），乳腺癌术后患者60例（D组），分别采集四组患者的血清，用酶联免疫吸附法（ELISA法）分别检测血清中IL-1β、IL-8、基质蛋白酶．2／9的表达水平。结果与C组[（35．93±3．44）ng／L、（17．63±2．73）ng／L、（91．55±2．43）ng／L、（99．71±3．94）ng／L]比较，A、D组血清中IL-1β、IL-8、MMP-2、MMP-9的表达水平明显增高：A组分别为（154．75±4．45）ng／L、（62．88±3．16）ng／L、（213．04±2．51）ng／L、（253．04±2．51）ng／L，差异均有统计学意义（t=128．21、66．90、219．59、224．38，均P〈0．05），D组分别为（104．75±3．78）ng／L、（39．94±3．16）ng／L、（148．26±2．31）ng／L、（153．04±2．51）ng／L，差异均有统计学意义（均P〈0．05），与C组比较，B组血清中IL-1β、IL-8、MMP-2、MMP-9表达水平[（56．22±2．94）ng／L、（20．63±2．36）ng／L、（104．75±3．16）ng／L、（109．71±3．94）ng／L]无明显增高（t=24．56、4．55、5．38、4．55，均P〈0．05）；与A组比较，D组血清中IL-1β、IL-8、MMP-2、MMP-9的表达水平减少：（104．75±3．78）ng／L、（39．94±3．16）ng／L、（148．26±2．31）ng／L、（153．04±2．51）ng／L，差异均有统计学意义（t=66．33、39．76、147．14、218．22，均P〈0．05）。结论IL-1β、IL-8、MMP-2／9参与了乳腺癌的发生、发展过程，四者联合检测，对乳腺癌临床诊疗具有重要意义。Objective To detect the interleukin - 1β （ IL - 1β ）, interleukin - 8 （ IL - 8 ） and matrix metalloproteinase-2/9 （MMP- 2/9 ） levels in breast cancer patients, and to explore the relationship and clinical significance of IL - 1β, IL - 8 and MMP - 2 / 9 with development of breast cancer. Methods The serum samples of 60 cases with breast cancer （ A group ）, 30 cases of breast hyperplasia （ B group ）, 30 healthy subjects （ C group ）, 60 breast cancer patients one month after operation（ D group） were randomly collected. The serum levels of IL- 1β, IL - 8, MMP - 2/9 in the four groups were detected. Results Compared with C group [ （ 35.93 ± 3.44） ng/L, （ 17. 63 ± 2.73 ） ng/L, （ 91.55 ± 2.43 ） ng/L, （ 99.71 ± 3.94 ） ng/L], the IL - 1β, IL - 8, MMP - 2, MMP - 9 levels in A group[ （ 154.75 ± 4.45 ） ng/L, （62.88 ± 3. 16 ） ng/L, （ 2β.04 ± 2.51 ） ng/L, （ 253.04 ± 2.51 ） ng/L] and D group [ （ 1 04.75 ± 3.78 ） ng/L, （ 39.94 ± 3.16 ） ng/L, （ 148.26 ± 2.31 ） ng/L, （ 153.04 ± 2.51 ） ng/L ] were significantly increased ,the differences were statistically significant （A group： t = 128.21,66.90,219.59,224.38, all P 〈 0.05 ; D group ： all P 〈 0.05 ）. Compared with C group,the IL - 1 β, IL - 8, MMP - 2, MMP - 9 levels of B group were not significantly increased [ （56.22 ± 2.94 ） ng/L, （20. 63 ± 2.36）ng/L, （ 104. 75 ± 3. 16 ） ng/L, （ 109. 71 ± 3.94） ng/L] （t =24.56,4.55,5.38,4.55 ,all P 〈 0.05）. Compared with A group,the IL - 1β,IL - 8, MMP - 2, MMP - 9 levels of D group were significantly reduced, the differences were statistically significant （ t = 66.33,39.76, 147.14,218.22,all P 〈 0.05 ）. Conclusion There is a close relationship between IL - 1β, IL - 8, MMP - 2/9 and breast cancer development, combined detection of four indicators has important implication for clinical diagnosis and treatment of breast cancer.

关 键 词：白细胞介素1Β 白细胞介素8 基质金属蛋白酶2 基质金属蛋白酶9 乳腺肿瘤 

分 类 号：R737.9[医药卫生—肿瘤]