胃癌患者肿瘤局部免疫反应与预后的关系  

Relationship between local tumor immune response and prognosis in patients with gastric carcinoma

作　　者：郭洪胜 郑妮 李淑贤 周世雄 贺晓舟 王森 黎鹏 GUO Hong-sheng;ZHENG Ni;LI Shu-xian;ZHOU Shi-xiong;HE Xiao-zhou;WANG Sena;LI Peng~＊(School of Basic Medicine, Guangdong Medical University, Dongguan 523800, China;Department of Pathology, Liuzhou Worker＇s Hospital, Liuzhou 545005, China)

机构地区：[1]广东医科大学基础医学院,广东东莞523808 [2]广西柳州市工人医院病理科,广西柳州545005

出　　处：《广东医科大学学报》2017年第6期617-621,共5页Journal of Guangdong Medical University

基　　金：广东省科技计划项目(No.2016A020215147);广东省卫生厅医学科研基金(No.A2016208;No.A2017605);广东医科大学科研基金(No.M2016026)

摘　　要：目的探讨胃癌患者肿瘤局部免疫反应与预后的关系。方法收集250例胃癌手术患者的临床病理资料,并按局部免疫反应分为淋巴上皮瘤样癌(LELC)、克罗恩样淋巴细胞反应样癌(CLR)和普通胃腺癌(CA)3种亚型,分析这些亚型与临床病理特点及预后的关系。结果 250例胃癌中CLR亚型139例(55.6%),CA亚型106例(42.4%),LELC亚型5例(2.0%)。与LELC、CLR亚型比较,CA亚型中Ⅳ期、远处转移较多,生存时间较短(P<0.05)。结论胃癌局部免疫反应分型可作为预后指标,其中CA亚型预后最差。Objective To investigate the relationship between local tumor immune response and prognosis in patients with gastric cancer. Methods Clincal and pathological data of 250 surgical patients with gastric cancer were enrolled. The samples of gastric cancer were subdivided into lymphoepithelioma like carcinoma（LELC）, Crohn＇s like lymphocytes reaction of mucoepidermoid carcinoma（CLR）, and conventional adenocarcinoma（CA） based on local immune response. The relationship between 3 subtypes and clinicopathological features and prognosis were analyzed. Results There were 5（2.0%）LELC, 139（55.6%） CLR and 106（42.4%） CA subtypes in 250 cases of gastric cancer. Compared with LELC and CLR subtypes, the stage IV and distant metastasis were more common but survival time was shorter in CA subtype（P〈0.05）.Conclusion The local immune response of gastric cancer may be a prognostic marker,of which CA subtype is the worst.

关 键 词：胃癌 局部免疫反应 预后 

分 类 号：R735.2[医药卫生—肿瘤]