中医阴阳学说指导下的DNA甲基化研究思路  

DNA Methylation Research Ideas under the Guidance of Chinese Medicine Yin-yang Theory

作　　者：周庆兵[1] 吴立旗[1] 张颖[1] 张萍[1] 童文新[1] 徐凤芹[1] ZHOU Qingbing, WU Liqi, ZHANG Ying, ZHANG Ping, TONG Wenxin, XU Fengqin(Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091)

机构地区：[1]中国中医科学院西苑医院,北京市海淀区西苑操场1号100091

出　　处：《中医杂志》2018年第7期561-564,共4页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81603490);中国博士后基金(2016M590187)

摘　　要：中医理论认为,阴阳失调是疾病发生与发展的关键,通过调和阴阳使"阴阳自和"是中医治疗疾病的目标。认为阴阳失调的部分现代生物学基础在于DNA甲基化的失控(包括异常的高甲基化与低甲基化)。从中医阴阳的"自和"角度出发,调节疾病异常的高甲基化基因与异常的低甲基化基因,使其恢复正常,对于上述疾病的治疗具有重大意义。提出在进行中药干预疾病异常基因甲基化水平的相关研究时,不仅要关注其去甲基化效应,同时还应关注其促甲基化作用,即中药的双向甲基化调控作用。In Chinese medicine theory,Yin-yang disorder is the key to the occurrence and development of diseases. Attaining ＂natural harmony of Yin-yang＂by regulating Yin-yang is the goal of Chinese medicine treating diseases. The authors think that part of the modern biological basis of Yin-yang disorder is uncontrolled DNA methylation（including abnormal hypermethylation and hypomethylation）. From the aspect natural harmony of Yin-yang in Chinese medicine,regulating abnormal hypermethylation genes and abnormal hypomethylation genes of diseases to normal condition is of great significance to treat diseases. The authors put forward that when making related researches of disease abnormal genes methylation levels by Chinese medicine intervention,not only should the demethylation effect be emphasized,but also the effect of promoting methylation should be considered,which is the bidirectional methylation regulation effect of Chinese medicine.

关 键 词：DNA甲基化 阴阳自和 高甲基化 低甲基化 

分 类 号：R226[医药卫生—中医基础理论]