奥拉西坦联合神经节苷脂治疗小儿脑损伤的临床观察  

Observation of the ganglioside combined with oxiracetam in the treatmentof children brain damage

作　　者：孙楠[1] 刘倩[1] 高山[1] 周建超[1] SUN Nan, LIU Qian , GAO Shan , ZHOU Jianchao(The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Chin)

机构地区：[1]郑州大学第三附属医院,河南郑州450000

出　　处：《中国实用神经疾病杂志》2018年第6期626-628,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的分析神经节苷脂联合奥拉西坦治疗小儿脑损伤的疗效。方法选取2016-01—2016-10收治的小儿脑损伤患者100例,随机分为对照组和实验组各50例。对照组在常规治疗的基础上接受神经节苷脂治疗;实验组在常规治疗基础上接受神经节苷脂联合奥拉西坦治疗,2组患者均治疗1次/d,14d为1个疗程,2个疗程间隔14d,持续治疗3个疗程。对比分析2组患儿的症状改善时间、住院时间、神经行为功能评分和临床疗效。结果治疗3个疗程后,2组患儿神经行为功能评分均得到明显提高,且实验组在治疗3个疗程后的评分明显高于对照组,差异有统计学意义(P=0.04);实验组治疗有效27例,对照组20例,实验组有效率明显高于对照组,差异有统计学意义(P<0.05)。结论奥拉西坦可明显改善脑损伤患儿的抽搐症状,联合神经节苷脂能够有效改善脑损伤患儿的临床症状和神经行为功能,安全性高,有推广意义。Objective To investigate the clinical effect of ganglioside combined with oxiracetam in the treatment of children with brain injury. Methods 100 cases of brain damage children in the hospital from January 2016 to October 2016 were enrolled and randomly divided into the control group and the experimental group, 50 children in each group. Among them, the patients in the control group was treated withganglioside; the experimental group was treated with ganglioside combined with oxiracetam treatment on the basis of routine treatment. Two groups of patients were treated once a day. Treatment time was 14 days. The two courses of treatment was14 days apart. Continuous treatment was lasted for 3 courses. The recovery time, the time of hospital stay,neurobehavioral score and the clinical efficacy were compared. Results After 3 courses of treatment,neurological, function score of children in two groups was significantly improved. The score of the experimental group was significantly higher than that of the control group, the difference was statistically significant （P =0.04）. In addition, the effective number of treatment in the ex perimental group was significantly higher than that in the control group. Conclusion Oxiracetam has obvious advantages in improving the symptoms of brain injury in children with convulsion. Ganglioside combined with Oxiracetam is an effective method for treatment of children with brain damage, can improve the neurobehavioral function of childrenwith high security. It is of significance in the clinical treatment of brain damage in children.

关 键 词：神经节苷脂 奥拉西坦 小儿 脑损伤 神经行为功能评分 

分 类 号：R748[医药卫生—神经病学与精神病学]