Toxocara optic neuropathy: clinical features and ocular findings  

作　　者：Kwang-Dong Choi Jae-Hwan Choi Seo-Young Choi Jae Ho Jung 

机构地区：[1]Department of Neurology, Pusan National University Hospital [2]Medical Research Institute, Pusan National University [3]Department of Neurology, Pusan National University Yangsan Hospital [4]Department of Ophthalmology, Pusan National University Yangsan Hospital [5]Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital

出　　处：《International Journal of Ophthalmology(English edition)》2018年第3期520-523,共4页国际眼科杂志（英文版）

摘　　要：We evaluated thirteen eyes of twelve patients diagnosed clinically and serologically with Toxocara optic neuropathy. Eleven patients had unilateral involvement and one patient had bilateral optic neuropathy. Eight patients （66.7%） had a possible infection source to Toxocara. Six patients （50%） had painless acute optic neuropathy. Ten eyes had asymmetric, sectorial optic disc edema with peripapillary infiltration and three eyes had diffuse optic disc edema. Eosinophilia was noted in five patients （41.7%） and optic nerve enhancement was observed in eight of eleven eyes （72.7%） with available orbit magnetic resonance imaging （MRI）. Mean visual acuity significantly improved following treatment [mean logarithmic of the minimum angle of resolution （IogMAR） 0.94±0.56 at baseline and 0.47±0.59 at the final （P=0.02）]. Asymmetric optic disc edema with a peripapillary lesion and a history of raw meat ingestion were important clues for diagnosing Toxocara optic neuropathy. Additionally, Toxocara IgG enzymelinked immunosorbent assay （ELISA） test and evaluating eosinophil may be helpful for diagnosis.We evaluated thirteen eyes of twelve patients diagnosed clinically and serologically with Toxocara optic neuropathy. Eleven patients had unilateral involvement and one patient had bilateral optic neuropathy. Eight patients （66.7%） had a possible infection source to Toxocara. Six patients （50%） had painless acute optic neuropathy. Ten eyes had asymmetric, sectorial optic disc edema with peripapillary infiltration and three eyes had diffuse optic disc edema. Eosinophilia was noted in five patients （41.7%） and optic nerve enhancement was observed in eight of eleven eyes （72.7%） with available orbit magnetic resonance imaging （MRI）. Mean visual acuity significantly improved following treatment [mean logarithmic of the minimum angle of resolution （IogMAR） 0.94±0.56 at baseline and 0.47±0.59 at the final （P=0.02）]. Asymmetric optic disc edema with a peripapillary lesion and a history of raw meat ingestion were important clues for diagnosing Toxocara optic neuropathy. Additionally, Toxocara IgG enzymelinked immunosorbent assay （ELISA） test and evaluating eosinophil may be helpful for diagnosis.

关 键 词：optic neuropathy TOXOCARIASIS ocular toxocariasis Toxocara optic neuropathy 

分 类 号：R77[医药卫生—眼科]