视网膜分支静脉阻塞黄斑水肿不同疗法的效果  

Efficacy of different methods of treatment for macular edema secondary to branch retinal vein occlusion

作　　者：马丽[1] 沈玲[1] 侯明杰[1] 许超[1] Ma Li, Shen Ling, Hou Mingjie, Xu Chao(Department of Ophthalmology, People＇s Hospital of Jiaozuo, Jiaozuo, Henan 454002, Chin)

机构地区：[1]焦作市人民医院眼科,河南454002

出　　处：《中华眼外伤职业眼病杂志》2018年第3期176-179,共4页Chinese Journal of Ocular Trauma and Occupational Eye Disease

摘　　要：目的比较视网膜分支静脉阻塞继发黄斑水肿的不同治疗方法的效果。方法前瞻性分析2015年6月至2017年2月视网膜分支静脉阻塞继发黄斑水肿64例（64只眼）的临床资料，随机分成2组其中接受玻璃体内注射曲安奈德并视网膜光凝术者32例（32只眼）为A组；玻璃体内注射雷珠单抗并视网膜光凝术者32例（32只眼）为B组。随访6个月，比较两组术后视力、黄斑中心区视网膜厚度（CMT）、复发率及并发症情况。结果最佳矫正视力（BCVA，Log MAR）：A、B两组术前分别为（0．72±0．19）和（0．74±0．23），两组差异无统计学意义（P〉0．05）；术后6个月两组分别为（0．53±0．27）和（0．36±0．26），均获得显著改善（P=0．002，0．000），而B组优于A组（P=0．013）。两组手术前后CMT差异均无统计学意义（P〉0．05）。术后A组复发率（25．0％）高于B组（3．1％），差异有统计学意义（P=0．031）。治疗期间均未见明显不良反应。结论玻璃体内注射雷珠单抗联合黄斑中心区视网膜光凝治疗视网膜分支静脉阻塞继发黄斑水肿具有较好的临床疗效。Objective To compare the efficacy of different treatments for macular edema secondary to branch retinal vein occlusion. Methods The data of 64 eyes of 64 cases of macular edema secondary to branch retinal vein occlusion from Jun. 2015 to Feb. 2017 were analyzed prospectively. Group A, 32 eyes of 32 patients, received intravitreal injection of Triamcinolone acetonide and retinal photocoagulation. Group B, 32 eyes of 32 patients, underwent intravitreal Lucentis injection and retinal photocoagulation. The follow-up time was 6 months. The visual acuity, central macular retinal thickness （CMT）, the recurrence and complications were compared between the two groups. Results The BCVA （LogMAR） of group A and group B were （0.72 ±0.19） and （0.74±0.23） before surgery. The difference in BCVA before operation was not significant between the two groups （P 〉 0.05）. Six months after operation, BCVA of group A and group B were （0.53 ±0.27） and （0.36 ±0.26）. The BCVA of two groups were improved after operation （P = 0. 002, 0. 000）. BCVA of group B was better than that of group A （P = 0. 013）. The difference in CMT was not significant between the two groups （P 〉 0.05 ）. The recurrence rate of group A was 25.0% after operation, which was higher than that of group B （3.1%） （P =0.031 ）. No obvious adverse reaction during treatment occurred. Conclusion Intravitreal injection of Ranibizumab combined with retinal photocoagulation for the treatment of macular edema secondary to branch retinal vein occlusion is effective.

关 键 词：黄斑水肿 视网膜分支静脉阻塞 雷珠单抗 玻璃体内注射 视网膜光凝 视力 

分 类 号：R779.6[医药卫生—眼科]