血浆神经递质浓度与产后抑郁症的关系（英文）  

Plasma concentrations of neurotransmitters and postpartum depression

作　　者：谢日华 谢海艳[3] Daniel Krewski[2] 何国平 XIE Rihua1,2, XIE Haiyan3, Daniel Krewski2, HE Guoping4(1. Department of Nursing, Nanhai Hospital, Southern Medical University, Foshan Guangdong 528244,China; 2. McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa Ontario KIN 6N5, Canada; 3. Department of Aging Industry, Changsha Social Work College, Changsha 410004, China; 4. Department of Community Nursing, Xiangya School of Nursing, Central South University, Changsha 410013, Chin)

机构地区：[1]南方医科大学南海医院护理部,广东佛山528244 [2]渥太华大学McLaughlin人群健康风险评估中心 [3]长沙民政职业技术学院老龄产业系,长沙410004 [4]中南大学湘雅护理学院社区护理教研室,长沙410013

出　　处：《中南大学学报（医学版）》2018年第3期274-281,共8页Journal of Central South University ：Medical Science

基　　金：supported by the Natural Science Foundation of Hunan Province (06JJ4055);the Project of Hunan Provincial Science and Technology Department (06FJ4103);the Project of Hunan Provincial Education Department (06C072), China

摘　　要：目的:探讨血浆神经递质与产后抑郁症(postpartum depression,PPD)的关联。方法:于2007年2至9月在湖南长沙3家三甲医院开展一项前瞻性巢式病例对照研究。运用爱丁堡产后抑郁量表(Edinburgh Postnatal Depression Scale,EPDS)中文版对产后2周产妇进行PPD筛查,得分≥13分者确定为PPD患者(n=42)。每个PPD患者按1:1抽取正常产妇为对照组(n=42),两组按照分娩医院(同一医院)与年龄(±5岁)进行匹配。在产后2周抽取血液样本,比较PPD组和对照组产妇的血浆单胺类递质及肽类神经递质水平,其中血浆单胺类递质包括5-羟色胺(5-hydroxytryptamine,5-HT)、多巴胺(dopamine,DA)、去甲肾上腺素(norepinephrine,NE),肽类神经递质包括神经肽Y(neuropeptide Y,NPY)和P物质(substance P,SP)。结果:PPD组5-HT和NPY血浆水平明显低于对照组,而NE和SP血浆水平明显高于对照组(均P﹤0.05)。PPD组NPY和NE血浆水平之间呈负相关(r=–0.36,P﹤0.05)。结论:PPD产妇存在多种神经递质水平的改变,不同神经递质之间具有潜在相互作用。Objective： To determine associations between postpartum depression （PPD） and plasma neurotransmitters. Methods： We conducted a case-control study nested to a prospective cohort established in 3 comprehensive tertiary hospitals in Changsha, Hunan, China from February to September 2007. The Chinese version of the Edinburgh Postnatal Depression Scale （EPDS） was used at 2 weeks postpartum to screen PPD, with a score of 13 or higher as the cut-off for PPD. The women with matched age but without PPD and delivery within 5 years were selected as controls. The levels of plasma monoamine neurotransmitters including serotonin （5-hydroxytryptamine, 5-HT）, dopamine （DA）, and norepinephrine （NE）, and peptide neurotransmitters including neuropeptide Y （NPY） and substance P （SP） in maternal blood samples taken at 2 weeks postpartum were measured and compared between PPD women （n=42） and controls （n=42）. Results： Plasma levels of 5-HT and NPY were significantly lower while plasma levels of NE and SP were significantly higher in PPD women than those in the controls. For women with PPD, a negative correlation between NPY and NE （r=-0.36, P〈0.05） was observed. Conclusion： There are changes in plasma levels of neurotransmitters in women with PPD, and there are potential interactions between different neurotransmitters.

关 键 词：产后抑郁症 5-羟色胺 去甲肾上腺素 神经肽Y P物质 

分 类 号：R749.4[医药卫生—神经病学与精神病学]