补肾化痰益智方联合丁苯酞对阿尔茨海默病患者氧化应激、血流变学及认知功能的影响  

Clinical Efficacy of Bushen Huatan Yizhi Decoction Combined with Butylphthalide and Effect on Oxidative Stress,Hemorheology and Cognitive Function in Patients with Alzheimer’s Disease

作　　者：王澍 张雪 马樱芮 赵吉波 WANG Shu1 , ZHANG Xue2, MA Ying-rui3, ZHAO Ji-bo1(（1. The Third Affiliated Hospital, Qiqihar Medical College, Qiqihar 161000, China; 2. Jianhua Hospital of Qiqihar , Qiqihar 161000, China; 3. Qiqihar Hospital of Traditional Chinese Medicine, Qiqihar 161000, Chin)

机构地区：[1]齐齐哈尔医学院附属第三医院,黑龙江齐齐哈尔161000 [2]齐齐哈尔市建华医院,黑龙江齐齐哈尔161000 [3]齐齐哈尔市中医医院,黑龙江齐齐哈尔161000

出　　处：《中国实验方剂学杂志》2018年第7期212-216,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：齐齐哈尔市2016年市级指导性科技计划项目(黑齐科鉴字[2016]第070号)

摘　　要：目的：探讨补肾化痰益智方联合丁苯酞对阿尔茨海默病（Alzheimer’s disease，AD）患者氧化应激、血流变学及认知功能的影响。方法：2014年3月-2016年4月齐齐哈尔医学院附属第三医院共收治127例AD患者，以该批患者为研究对象，按随机数字表法分为治疗组（63例），对照组（64例）。两组患者同时给予丁苯酞软胶囊，在此基础上，治疗组加服补肾化痰益智方，连续治疗3个月后，对两组患者临床疗效，氧化应激、血液流变学与简易智力状态检查法（mini-mental state examination，MMSE）量表评分进行比较。结果：治疗组患者总有效率为93．65％，对照组为81．25％，治疗组高于对照组（P〈0．05）；经治疗，两组AD患者全血高、低切黏度，红细胞聚集指数与红细胞压积均明显降低，且治疗组明显低于对照组（P〈0．05）；与治疗前比较，治疗后，两组患者超氧化物歧化酶（super oxide dismutase，SOD），谷胱甘肽过氧化物酶（glutathione peroxidase，GPX-3）及过氧化氢酶（catalase，CAT）均明显提高，丙二醛（malonyldialdehyde，MDA）明显降低，且治疗组效果明显优于对照组（P〈0．05）；与治疗前比较，治疗后两组MMSE评分及记忆力、注意力和计算力、定向力、语言能力、回忆能力均明显改善，且治疗组明显优于对照组（P〈0．05）。结论：补肾化痰益智方联合丁苯酞可以明显提高AD患者的认知功能，改善患者血液流变学，降低氧化刺激损伤，因此对AD具有积极的治疗效果。Objective： To study the clinical efficacy of Bushe Huatan Yizhi decoction combined with butylphthalide and effect on oxidative stress, hemorheology and cognitive function in patients with Alzheimer＇s disease （AD）. Method： The 127 patients with AD treated in The Third Affiliated Hospital, Qiqihar Medical College from March 2014 to April 2016 were selected in this study and divided into two groups according to the random number table, with 63 cases in treatment group and 64 cases in control group. Patients in control group were treated with butylphthalide soft capsules, and on this basis, the patient in treatment group were given with additional Bushe Huatan Yizhi decoction. After 3 months treatment, the treatment efficacy, oxidative stress, hemorheology and mini-mental state examination （MMSE） scores were compared. Result： The total effective rate was 93.65% in treatment group, higher than 81.25% in control group （P 〈 0.05）. After treatment, the hematocrit, the whole blood viscosity at low shear rate, whole blood viscosity, erythrocyte aggregation index were decreased significantly in both groups, and the levels in treatment group were lower than those in control group （P 〈 0.05）. As compared with the conditions before treatment, the levels of malonyldialdehyde （MDA） were decreased while super oxide dismutase （SOD）, glutathione peroxidase （GSH-Px） and catalase （CAT） were increased in both groups after treatment, and the effect was more obvious in treatment group （P 〈 0.05）. After treatment, MMSE scores and the scores of memory, attention, computational power, orientation, language ability, and recall ability were improved in both groups, and the effects were more obvious in treatment group （P 〈 0.05）. Conclusion： Bushe Huatan Yizhi decoction combined with butylphthalide can significantly improve cognitive function and hemorheology, and lower oxidative stress levels in patients with AD, so it has positive therapeutic effect on AD.

关 键 词：补肾化痰益智方 阿尔茨海默病 氧化应激 血流变学 认知功能 

分 类 号：R22[医药卫生—中医基础理论] R24[医药卫生—中医学]