降钙素原与乳酸和C-反应蛋白检测在感染性休克中意义及对预后评估价值分析  

Significance of procalcitonin,lactic acid and C reactive protein detection in septic shock and its prognostic value

作　　者：章娅妮 黄桔秀[1] 朱海勇[2] 翁丹凤 朱宏波[3] ZHANG Ya-ni, HUANG Ju-xiu, ZHU Hai-yong, WENG Dan-feng, ZHU Hong-bo(Taizhou Central Hospital, Taizhou , Zhejiang 318000, Chin)

机构地区：[1]台州市中心医院急诊内科,浙江台州318000 [2]台州市中心医院EICU,浙江台州318000 [3]台州市中心医院ICU,浙江台州318000

出　　处：《中华医院感染学杂志》2018年第6期841-843,共3页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生基金资助项目(2015KYA234)

摘　　要：目的探讨降钙素原(PCT)、乳酸和C-反应蛋白(CRP)检测在感染性休克中的意义及对预后评估价值。方法选取于2012年1月-2017年1月期间医院收治的感染性休克患者153例为研究对象,根据预后情况,转出ICU/EICU患者107例为生存组,死亡患者46例为死亡组;分别抽取外周静脉血,分离血清,PCT检测方法为免疫发光分析法,乳酸检测方法为干化学法,CRP检测方法为酶速率散射比浊法;观察分析两组患者入院时急性生理与慢性健康评分(APACHEⅡ评分)和白细胞计数(WBC)水平,入院后1、3、5dPCT、乳酸和CRP水平。结果入院时,生存组患者APACHEⅡ评分为(18.49±3.46)分与WBC水平为(10.89±1.68)×109/L,低于死亡组患者(P<0.05);入院后1、3、5d,生存组患者PCT、乳酸和CRP水平低于同期死亡组患者(P<0.05);生存组患者PCT、乳酸和CRP水平比较差异有统计学意义(P<0.05);死亡组患者PCT、乳酸和CRP水平比较差异有统计学意义(P<0.05)。结论 PCT、乳酸和CRP在感染性休克患者预后的评估中具有重要意义。OBJECTIVE To investigate the value of procalcitonin（PCT）,lactic acid and C reactive protein（CRP）in septic shock and its prognostic value.METHODS A total of 153 cases of patients with septic shock were selected from the hospital from Jan.2012 to Jan.2017.According to the prognosis,107 cases of patients transferred out of ICU/EICU were set as survival group,and 46 cases of death patients were set as death group.The peripheral blood samples were extracted,and the serum was separated.The immunoassay method was used to detect PCT,the dry chemical method was used to detect lactic acid,and the enzyme rate turbidimetry was used to detect CRP.The acute physiology and chronic health score（APACHE II score）and white blood cell count（WBC）at the time of admissionin,and the levels of PCT,lactate and CRP at 1,3,5 dafter admission were observed and analyzed.RESULTS At the time of admission,the APACHE Ⅱ score and WBC level of survival group were（18.49±3.46）points and（10.89±1.68）×109/L,which were lower than those of death group（P0.05）.At 1,3,5 dafter admission,the leves of PCT,lactic acid and CRP of survival group were lower than those of death group（P0.05）.There were significant differences in the levels of PCT,lactic acid and CRP in survival group（P0.05）.There were significant differences in the levels of PCT,lactic acid and CRP in death group（P0.05）.CONCLUSION PCT,lactic acid and CRP play an important role in the evaluation of prognosis in patients with septic shock.

关 键 词：降钙素原 乳酸 C-反应蛋白 感染性休克 预后 

分 类 号：R181.3[医药卫生—流行病学]