妇科肿瘤患者医院感染病原菌分布及治疗疗效研究  

Distribution of pathogens causing nosocomial infections in patients with gynecological tumor and curative effects

作　　者：韩树斋[1] 崔利德[2] 李铁民[3] 谢愿 杨士荣 HAN Shu-zhai, CUI Li-de, LI Tie-min, XIE Yuan, YANG Shi-rong(Jining Medical College Affiliated Hospital, Jining, Shandong 272029, Chin)

机构地区：[1]济宁医学院附属医院妇科,山东济宁272029 [2]济宁医学院解剖教研室,山东济宁272029 [3]河北大学附属医院检验科,河北保定071000

出　　处：《中华医院感染学杂志》2018年第6期929-932,共4页Chinese Journal of Nosocomiology

基　　金：山东省自然科学基金资助项目(ER2010HL038)

摘　　要：目的探讨妇科肿瘤患者医院感染菌种、部位分布及药物治疗疗效。方法选取2014年2月-2016年12月医院治疗的950例妇科肿瘤患者作为研究对象,观察患者的医院感染率,统计患者感染病原菌类型及部位分布,将发生医院感染的患者随机分为观察组和对照组,观察组患者采用克霉唑阴道片联合奈达铂治疗,对照组患者采用奈达铂静脉滴注治疗,比较两组患者的治疗效果。结果患者医院感染率为9.47%;患者感染革兰阴性菌、革兰阳性菌及真菌,分别占66.94%、25.62%及7.44%;患者感染部位以泌尿道和手术切口为主,分别占35.56%及31.11%;治疗后,两组患者白带增多、外阴瘙痒、手术切口红肿及阴道黏膜充血等症状发生率均有所降低,观察组患者各症状发生率均低于对照组患者(P<0.05)。结论妇科肿瘤患者医院感染病原菌以革兰阴性菌为主,感染部位多为泌尿道和手术切口,采用抗菌药物联合克霉唑阴道片联合治疗,效果较好,可在临床上推广。OBJECTIVE To explore the species of pathogens causing nosocomial infections in patients with gynecological tumor,analyze the infection sites and observe the curative effects.METHODS A total of 950 patients with gynecological tumor who were treated in hospitals from Feb 2015 to Dec 2016 were recruited as the study objects.The incidence of nosocomial infections was observed,the species of pathogens causing the infections and the infection sites were statistically analyzed,the patients with nosocomial infections were randomly divided into the observation group and the control group.The observation group was treated with clotrimazole vaginal tablets combined with nedaplatin,while the control group was given intravenous drip of nedaplatin.The curative effects were compared between the two groups of patients.RESULTS The incidence of nosocomial infections of the patients was 9.47%.Among the pathogens causing the infections,the gram-negative bacteria accounted for 66.94%,the grampositive bacteria 25.62%,the fungi 7.44%.Among the patients with the nosocomial infections,35.56% had urinary tract infections,and 31.11% had surgical incision infections.The incidence rates of the symptoms such as increased vaginal discharge,genital itching,surgical incision swelling and vaginal mucosal congestion were reduced in the two groups of patients,which were significantly lower in the observation group than in the control group（P0.05）.CONCLUSIONThe gram-negative bacteria are dominant among the pathogens causing the nosocomial infections in the patients with gynecological tumor,the urinary tract and surgical incision are the major infection sites,the antibiotics combined with clotrimazole vaginal tablets may achieve remarkable curative effect,and it is worthy to be promoted in the hospital.

关 键 词：妇科肿瘤 医院感染 病原菌 感染部位 疗效 

分 类 号：R737.3[医药卫生—肿瘤]