Microwave-assisted Synthesis of New 1,2,3-Triazoles Bearing an Isoxazole Ring by the Azide-alkyne Cycloaddition Click Chemistry  

作　　者：LI Jing LIU Hongwei MENG Fanyu YAN Liuqing SHI Yanpeng ZHANG Yumin GU Qiang 

机构地区：[1]College of Chemistry, Jilin University, Changchun 130012, P. R. China [2]National-Local Joint Engineering Laboratory of In-situ Conversion,Drilling and Exploitation Technology for Oil Shale, Changchun 130021, 17. R. China

出　　处：《Chemical Research in Chinese Universities》2018年第2期197-202,共6页高等学校化学研究（英文版）

摘　　要：A comparison synthesis of 1,2,3-triazoles bearing isoxazole ether was developed between conventional and microwave-assisted heating. Single/donble 1,2,3-triazoles bearing isoxazole ether were synthesized by click reaction starting from substituted isoxazolyl alkyne compounds and substituted benzyl azide compounds or neopen- tylglycol diazide in the presence of copper（I） that in-aim generated. Herein, the effect of different catalysts on the yield was researched by conventional method, and the optimal catalyst was selected. The structures of all the synthe- sized compounds were confirmed by MS, FTIR, ^1H and ^13C NMR spectroscopies. Moreover, the crystal structure of 5-{[（1-benzyl-1H-1,2,3-triazol-4-yl）methoxvlmethvl}-3-（4-fluoroohenvl）isoxazole（2h） was determined.A comparison synthesis of 1,2,3-triazoles bearing isoxazole ether was developed between conventional and microwave-assisted heating. Single/donble 1,2,3-triazoles bearing isoxazole ether were synthesized by click reaction starting from substituted isoxazolyl alkyne compounds and substituted benzyl azide compounds or neopen- tylglycol diazide in the presence of copper（I） that in-aim generated. Herein, the effect of different catalysts on the yield was researched by conventional method, and the optimal catalyst was selected. The structures of all the synthe- sized compounds were confirmed by MS, FTIR, ^1H and ^13C NMR spectroscopies. Moreover, the crystal structure of 5-{[（1-benzyl-1H-1,2,3-triazol-4-yl）methoxvlmethvl}-3-（4-fluoroohenvl）isoxazole（2h） was determined.

关 键 词：Microwave-assisted heating 1 2 3-TRIAZOLE ISOXAZOLE Azide-alkyne Click chemistry 

分 类 号：O6[理学—化学] V512[航空宇航科学与技术—航空宇航推进理论与工程]