ISOXAZOLE

作品数：31被引量：52H指数：3
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The Smallest Monofluorodiazoethane Reagent and Its[3+2]Cycloaddition Reactions
《CCS Chemistry》2024年第11期2825-2834,共10页Xiaodong Tang Ming-Yue He Ran Guo Hao-Nan Liu Jing Nie Ilan Marek Jun-An Ma Fa-Guang Zhang 
financial support provided by the National Natural Science Foundation of China(NSFC,grant nos.92156025 and 22271212);the National Key Research and Development Program of China(grant nos.2019YFA0905100 and 2021YFF0701700);X.T.thanks the China Postdoctoral Science Foundation(grant no.2022M712350).
Given the widespread applications of fluorinated substances in pharmaceuticals,biology,and materials,the development of fluorine-containing building blocks remains an important topic in organic chemistry.In the repert...
关键词：monofluoromethyl group diazo reagent cycloaddition reaction TETRAZOLE ISOXAZOLE fluorine chemistry 
A novel isoxazole compound CM2-II-173 inhibits the invasivephenotype of triple-negative breast cancer cells
《Oncology Research》2023年第6期867-875,共9页EUN SOOK KIM SANGHEE KIM AREE MOON 
supported by the National Research Foundation of Korea(Nos.2016R1A6A1A03007648,2019R1A2C1009773,2018R1A5A2024425,and 2022R1A2C1093335).
Invasion and metastasis are important hallmarks of breast cancer and are the leading cause of patient mortality.Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer characterized by a poor progn...
关键词：MMP-9 Cell invasion Breast cells 
Synthesis and Antitumor Activity of 3-[2-(4-Hydroxy-Phenyl)-Ethyl]-Benzo[d] Isoxazole-4,6-Diol
《International Journal of Organic Chemistry》2023年第1期1-6,共6页Li Wang 
A new phloretin derivative 1 3-[2-(4-hydroxy-phenyl)-ethyl]-benzo[d] isoxazole-4,6-diol (yield 63%) was synthesized from phloretin by carbonyl nucleophilic addition condensation reaction. Its structure was characteriz...
关键词：3-[2-(4-Hydroxy-Phenyl)-Ethyl]-Benzo[d] Isoxazole-4 6-Diol SYNTHESIS Antitumor Activity 
Design,synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl)sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia
《Acta Pharmacologica Sinica》2022年第10期2735-2748,共14页Mao-feng Zhang Xiao-yu Luo Cheng Zhang Chao Wang Xi-shan Wu Qiu-ping Xiang Yong Xu Yan Zhang 
This work was supported in part by grants from the Natural Science Foundation of Jiangsu province(BK20190246);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(19KJB350011);the National Key R&D Program of China(2019YFE0123700);the National Natural Science Foundation of China(81673357);the Guangdong Basic and Applied Basic Research Foundation(2019A1515110592);the Chinese Academy of Sciences STS Program(KFJ-STS-QYZX-090);the State Key Laboratory of Respiratory Disease(SKLRD-Z-202018);the China Postdoctoral Science Foundation,the Guangdong Provincial Postdoctoral Special Funding,Special Research Assistant Project of Chinese Academy of Sciences,Research Project of Taizhou Polytechnic College(TZYKYZD-21-1)。
BRD4 plays a key role in the regulation of gene transcription and has been identified as an attractive target for cancer treatment.In this study,we designed 26 new compounds by modifying 3-ethyl-benzo[d]isoxazole core...
关键词：acute myeloid leukemia BRD4 inhibitors 3-ethyl-benzo[d]isoxazole C-MYC CDK6 APOPTOSIS 
Novel insights on acetylcholinesterase inhibition by Convolvulus pluricaulis,scopolamine and their combination in zebrafish
《Natural Products and Bioprospecting》2022年第1期56-70,共15页Kalyani Bindu Karunakaran Anand Thiyagaraj Kirankumar Santhakumar 
financial assistance received from the Department of Biotechnology,Ministry of Science and Technology,New Delhi (BT/PR26189/GET/119/226/2017);DST-SERB,New Delhi (EMR/2017/000465).
Acetylcholinesterase(AChE)inhibitors increase the retention of acetylcholine(ACh)in synapses.Although they allevi-ate cognitive deficits in Alzheimer’s disease,their limited benefits warrant investigations of plant e...
关键词：Alzheimer’s disease ACETYLCHOLINESTERASE ZEBRAFISH Convolvulus pluricaulis SCOPOLAMINE ISOXAZOLE 
Microwave-assistant Syntheses, Crystal Structures and Safener Activities of Two Substituted Phenyl Isoxazole Derivatives
《Chinese Journal of Structural Chemistry》2021年第9期1231-1237,1111,共8页GAO Ying-Chao SHAO Xin-Xin FU Ying 
the National Natural Science Foundation of China(No.31801784 and 31572042);Undergraduate SIPT program of Northeast Agricultural University(No.202010224112)。
Two novel substituted phenyl isoxazole benzoxazine formamide derivatives were designed and synthesized with substituted o-aminophenol,1,2-dibromoethane and different phenyl substituted isoxazole formyl chloride as the...
关键词：isoxazole benzoxazine formamide microwave-assistant synthesis single-crystal structure safener activity 
Design,Ultrasonic-assisted Synthesis and Evaluation In vitro Antimicrobial Activity of Bis-isoxazole Derivatives Bearing Chloro-pyridinyl Group
《Chemical Research in Chinese Universities》2021年第3期668-673,共6页FENG Fan LI Jing ZHANG Zhihui FU Jiaxu ZHANG Yumin GU Qiang 
An ultrasonic-assisted synthesis of bis-isoxazole derivatives was developed.Eight 3-(6-chloropyridin-3-yl)-5-{[(3-arylisoxazol-5-yl)methoxy]methyl}isoxazoles were synthesized by 1,3-dipolar cycloaddition reaction betw...
关键词：ULTRASONIC-ASSISTED Bis-isoxazole 1 3-Dipolar cycloaddition Antimicrobial activity 
Microwave Assistant Synthesis and Crystal Structures of Two Substituted Oxazole Isoxazole Carboxamides被引量：1
《Chinese Journal of Structural Chemistry》2020年第10期1906-1911,1746,共7页KANG Tao LIU Cheng-Guo WU Shi-Long GAO Shuang YE Fei FU Ying 
the National Natural Science Foundation of China(Nos.31801784 and 31572042);Natural Science Foundation of Heilongjiang Province(No.ZD2017002);the Research Science Foundation in Technology Innovation of Harbin(No.2017RAQXJ0172)。
Two novel substituted phenyl oxazole isoxazole carboxamides have been synthesized by microwave assistant technology.The target compounds were characterized by IR,1H NMR,13C NMR and HRMS,and their single-crystal struct...
关键词：oxazole isoxazole carboxamides single-crystal structure synthesis bioactivity 
Modified constraint-induced movement therapy alters synaptic plasticity of rat contralateral hippocampus following middle cerebral artery occlusion被引量：20
《Neural Regeneration Research》2020年第6期1045-1057,共13页Bei-Yao Gao Dong-Sheng Xu Pei-Le Liu Ce Li Liang Du Yan Hua Jian Hu Jia-Yun Hou Yu-Long Bai 
supported by the National Natural Science Foundation of China,No.81871841(to YLB) and No.81772453(to DSX)
Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb and limiting the contralateral limb.Ho...
关键词：BRAIN-DERIVED NEUROTROPHIC factor glutamate HIPPOCAMPUS m CIMT middle cerebral artery occlusion MODIFIED constraint-induced movement therapy α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor 
Microwave-assisted Synthesis of New 1,2,3-Triazoles Bearing an Isoxazole Ring by the Azide-alkyne Cycloaddition Click Chemistry
《Chemical Research in Chinese Universities》2018年第2期197-202,共6页LI Jing LIU Hongwei MENG Fanyu YAN Liuqing SHI Yanpeng ZHANG Yumin GU Qiang 
A comparison synthesis of 1,2,3-triazoles bearing isoxazole ether was developed between conventional and microwave-assisted heating. Single/donble 1,2,3-triazoles bearing isoxazole ether were synthesized by click reac...
关键词：Microwave-assisted heating 1 2 3-TRIAZOLE ISOXAZOLE Azide-alkyne Click chemistry 
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