SCOPOLAMINE

作品数：54被引量：77H指数：5
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相关领域：医药卫生更多>>
相关作者：陈忠韩怡凡王留义王丽霞张永珍更多>>
相关机构：浙江大学中国科学院香港科技大学冈山大学更多>>
相关期刊：《Oil Crop Science》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《Pharmacology & Pharmacy》更多>>
相关基金：国家自然科学基金泰国研究基金国家重点基础研究发展计划国家科技支撑计划更多>>
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Salacia fruticosa methanol extract pretreatment attenuates scopolamine-induced cognitive decline and Alzheimer's disease-related pathology in zebrafish
《Asian Pacific Journal of Tropical Biomedicine》2025年第3期109-118,I0002-I0015,共24页Praveen Kumar Pasala DSNBK Prasanth Siva Prasad Panda Vaishnavi Munnangi Sharon Blessy Sheikh F.Ahmad Haneen A.Al-Mazroua 
funded by King Saud University,Riyadh,Saudi Arabia,Project Number(RSPD2025R709).
Objective:To examine the effect of the methanolic extract of Salacia fruticosa in a zebrafish model of scopolamine-induced Alzheimer’s disease.Methods:High-resolution liquid chromatography-mass spectrometry was used ...
关键词：SCOPOLAMINE Acetylcholinesterase inhibitors Salacia fruticosa ZEBRAFISH Molecular docking ANTIOXIDATION NEUROINFLAMMATION 
Ameliorative effect of walnut oil against cognitive impairment in alzheimers type dementia in rodent
《Oil Crop Science》2024年第4期234-239,共6页Congcong Ma Li Zhang Lei Wang Qingde Huang Qianchun Deng Fenghong Huang Jiqu Xu 
supported by the Key Technology R&D Program of Shandong Province(2023TZXD069);the National Natural Science Foundation of China(NSFC-U21A20274);the innovation group project of Hubei Province(2023AFA042);the Earmarked Fund for China Agriculture Research System(CARS-14);by Agricultural Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2016-OCRI).
Walnut oil(WO),known for abundant polyunsaturated fatty acids and an array of bioactive substances such as tocopherols,phytosterols,squalene,melatonin,and polyphenols,which is endowed with numerous health advantages.T...
关键词：Walnut oil SCOPOLAMINE Memory Morris water maze Step-down avoidance test Cholinergic system 
Scopolamine causes delirium-like brain network dysfunction and reversible cognitive impairment without neuronal loss被引量：4
《Zoological Research》2023年第4期712-724,共13页Qing Wang Xiang Zhang Yu-Jie Guo Ya-Yan Pang Jun-Jie Li Yan-Li Zhao Jun-Fen Wei Bai-Ting Zhu Jing-Xiang Tang Yang-Yang Jiang Jie Meng Ji-Rong Yue Peng Lei 
supported by the National Natural Science Foundation of China(82071191,82001129);Natural Science Foundation of Sichuan Province(2022NSFSC1509);National Clinical Research Center for Geriatrics of West China Hospital(Z2021LC001);West China Hospital 1.3.5 Project for Disciplines of Excellence(ZYYC20009)。
Delirium is a severe acute neuropsychiatric syndrome that commonly occurs in the elderly and is considered an independent risk factor for later dementia.However,given its inherent complexity,few animal models of delir...
关键词：DELIRIUM SCOPOLAMINE Cholinergic neuron Neuronal activity Brain network 
Antarctic krill peptides improve scopolamine-induced memory impairment in mice被引量：1
《Food Bioscience》2022年第5期999-1009,共11页Jingru Zheng Yuanhong Gao Jie Ding Na Sun Songyi Lin 
supported by National Natural Science Foundation of China[Grant No.32022067];Dalian Hih-level Talent Innovation Support Program of China[Grant No.2019RQ003].
The study aims to investigate the repair effects of Ser-Ser-Asp-Ala-Phe-Phe-Pro-Phe-Arg(SSDAFFPFR)and Ser-Asn-Val-Phe-Asp-Met-Phe(SNVFDMF)peptides on scopolamine-caused memory impairment in mice.Behavioral experiments...
关键词：Antarctic krill Bioactive peptide HIPPOCAMPUS Memory impairment Scopolamine mouse model Protein expression level 
Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction:role on apoptosis,inflammation and oxidative stress
《Food Science and Human Wellness》2022年第5期1290-1298,共9页GökselŞener Gözde Karakadıoglu Dilek Ozbeyli Seren Ede Refiye Yanardag Ozlem Sacan Asli Aykac 
This study was designed to investigate whether Petroselinum crispum(PC)extract has protective effects on the brain in the scopolamine-induced Alzheimer’s disease(AD)rat model.The rats were divided into;control,scopol...
关键词：Petroselinum crispum APOPTOSIS Spatial memory Recognition memory Oxidative stress M1 receptor 
Ginkgo Biloba Extract Ameliorates Scopolamine-induced Memory Deficits via Rescuing Synaptic Damage
《Current Medical Science》2022年第3期474-482,共9页Gui-jiao ZHANG Dong ZHENG Huan YU Xiao-ping LUO Wei WU 
the National Key Research and Development Project of China(No.2017YFC1309601).
Objective Alzheimer’s disease(AD)is the most common age-related neurodegenerative disorder.Emerging evidence suggests that synaptic dysfunction is associated with the onset and progression of AD.Interestingly,Ginkgo ...
关键词：Ginkgo biloba extract Alzheimer’s disease SYNAPSE PSD95 MIR-1 MiR-206 
Novel insights on acetylcholinesterase inhibition by Convolvulus pluricaulis,scopolamine and their combination in zebrafish
《Natural Products and Bioprospecting》2022年第1期56-70,共15页Kalyani Bindu Karunakaran Anand Thiyagaraj Kirankumar Santhakumar 
financial assistance received from the Department of Biotechnology,Ministry of Science and Technology,New Delhi (BT/PR26189/GET/119/226/2017);DST-SERB,New Delhi (EMR/2017/000465).
Acetylcholinesterase(AChE)inhibitors increase the retention of acetylcholine(ACh)in synapses.Although they allevi-ate cognitive deficits in Alzheimer’s disease,their limited benefits warrant investigations of plant e...
关键词：Alzheimer’s disease ACETYLCHOLINESTERASE ZEBRAFISH Convolvulus pluricaulis SCOPOLAMINE ISOXAZOLE 
Further Insights on the <i>Datura innoxia</i>Hyoscyamine 6<i>β</i>-Hydroxylase (DiH6H) Based on Biochemical Characterization and Molecular Modeling
《American Journal of Plant Sciences》2021年第1期53-70,共18页Daniel Schlesinger Faris Salama Rachel Davidovich Rikanati Rotem Sertchook Ofir Tal Mosaab Yahyaa Adi Faigenboim Mwafaq Ibdah Moshe Inbar Efraim Lewinsohn 
Hyoscyamine, anisodamine and scopolamine are tropane alkaloids present in some Solanaceae species and used in modern medicine. L-Hyoscyamine is hydroxylated to 6β
关键词：Hyoscyamine 6β Hydroxylase Datura innoxia. Mill. SOLANACEAE SCOPOLAMINE HYOSCYAMINE 
Suggested Two Hypotheses on Dementia (“Anticholinergic Hypothesis” and “Cranial Skeletal Muscles Hypothesis”) and the Therapeutic Agent
《Advances in Alzheimer's Disease》2019年第2期15-26,共12页Aibi Ivy Numazawa 
The present study was conducted with the objective of further developing the cholinergic hypothesis and not using the prevalent amyloid beta plaque hypothesis or the tau protein hypothesis on dementia. The experiment ...
关键词：DEMENTIA Alzheimer ANTICHOLINERGIC SCOPOLAMINE METHOCARBAMOL Ymaze Skeletal Muscles 
Kai Xin San ameliorates scopolamine-induced cognitive dysfunction被引量：13
《Neural Regeneration Research》2019年第5期794-804,共11页Yu-Min Xu Xin-Chen Wang Ting-Ting Xu Hong-Ying Li Shang-Yan Hei Na-Chuan Luo Hong Wang Wei Zhao Shu-Huan Fang Yun-Bo Chen Li Guan Yong-Qi Fang Shi-Jie Zhang Qi Wang Wei-Xiong Liang 
supported by the National Natural Science Foundation of China,No.81473740,81673627,81673717(to QW);Guangzhou Science Technology and Innovation Commission Technology Research Projects,China,No.2018050100(to QW);the Foundation for Characteristic Innovation of Educational Commission of Guangdong Province,China,Grant No.2016KTSCX011(to SHF);the Open Tending Project for Construction of High-Level University,Guangzhou University of Chinese Medicine,China,No.34 and 118,2017(to SHF);the Technology Platform of Clinical Trials on New Traditional Medicine,China,No.2012ZX09303009-003(to WXL);the Technology Platform of Clinical Evaluation on New Traditional Medicine,China,No.2008ZX09312-021(to WXL)
Kai Xin San(KXS, containing ginseng, hoelen, polygala, and acorus), a traditional Chinese herbal compound, has been found to regulate cognitive dysfunction; however, its mechanism of action is still unclear. In this s...
关键词：Kai Xin SAN cognitive DYSFUNCTION SCOPOLAMINE hydrobromide neuroprotection oxidative stress SYNAPTIC DYSFUNCTION apoptosis CHOLINERGIC system DYSFUNCTION DONEPEZIL neural regeneration 
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