SYNAPTIC

作品数：319被引量：717H指数：13
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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching
《Neural Regeneration Research》2025年第9期2624-2632,共9页Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy 
supported by NIH grants AG079264(to PHR)and AG071560(to APR)。
The process of neurite outgrowth and branching is a crucial aspect of neuronal development and regeneration.Axons and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are use...
关键词：diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule 
The role of axon guidance molecules in the pathogenesis of epilepsy
《Neural Regeneration Research》2025年第5期1244-1257,共14页Zheng Liu Chunhua Pan Hao Huang 
supported by the National Natural Science Foundation of China,Nos. 81760247, 82171450;the Scientific Research Foundation for Doctors of the Affiliated Hospital of Zunyi Medical University,No.(2016)14 (all to HH)。
Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target no...
关键词：axon guidance drug-resistant epilepsy EPILEPSY nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity NEURONS synaptic remodeling 
Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly
《Neural Regeneration Research》2025年第5期1409-1410,共2页Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela 
Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic plasticity.AD has progressively been recognized as syna ptopathy and ...
关键词：ALZHEIMER PATHOLOGY 
Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy被引量：1
《Fundamental Research》2025年第1期63-71,共9页Xiuhong Lu Bin Ji Gang Huang Hong Ding 
funding support from the National Natural Science Foundation of China(81971016);Shanghai Science and Technology program(21010502300);Construction project of Shanghai Key Laboratory of Molecular Imaging(18DZ2260400).
Dementia is characterized by synaptic and neuronal dysfunction in disease-specific brain regions.Repeated failure of dementia clinical trials with therapeutic drugs targeting abnormal protein aggregates has caused res...
关键词：Synaptic density imaging Synaptic vesicle protein 2A DEMENTIA Multimodal imaging UCB-J Positron emission tomography 
Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation
《Neural Regeneration Research》2025年第2期326-342,共17页Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai Wang 
supported by the Hefei Comprehensive National Science Center Hefei Brain Project(to KW);the National Natural Science Foundation of China,Nos.31970979(to KW),82101498(to XW);the STI2030-Major Projects,No.2021ZD0201800(to PH).
Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and homeostasis.The Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neur...
关键词：Alzheimer’s disease amyloid deposition apoptotic mechanisms BIOMARKER neural regeneration NEURODEGENERATION repetitive transcranial magnetic stimulation synaptic plasticity 
Recent progress in organic optoelectronic synaptic transistor arrays:fabrication strategies and innovative applications of system integration被引量：1
《Journal of Semiconductors》2025年第2期72-86,共15页Pu Guo Junyao Zhang Jia Huang 
supported by the National Key Research and Development Program of China(2021YFA1101303);the National Natural Science Foundation of China(62374115);the Innovation Program of Shanghai Municipal Education Commission(2021-01-07-00-07-E00096).
The rapid growth of artificial intelligence has accelerated data generation,which increasingly exposes the limitations faced by traditional computational architectures,particularly in terms of energy consumption and d...
关键词：organic transistor arrays optoelectronic synaptic transistors neuromorphic systems system integration 
Deep-UV-photo-excited synaptic Ga_(2)O_(3) nano-device with low-energy consumption for neuromorphic computing
《Journal of Semiconductors》2025年第2期88-96,共9页Liubin Yang Xiushuo Gu Min Zhou Jianya Zhang Yonglin Huang Yukun Zhao 
financially supported by the Key Research Program of Frontier Sciences,CAS (No. ZDBS-LYJSC034);National Natural Science Foundation of China (No.62174172);China Postdoctoral Science Foundation (Nos.2023TQ0238 and 2023M742560);Basic Research Pilot Project of Suzhou (No. SSD2024003);Jiangsu Key Disciplines of the Fourteenth Five-Year Plan (No. 2021135)
Synaptic nano-devices have powerful capabilities in logic,memory and learning,making them essential compo-nents for constructing brain-like neuromorphic computing systems.Here,we have successfully developed and demons...
关键词：Ga_(2)O_(3)nanowires synaptic nano-device low energy consumption neural network 
Nanowatt-level optoelectronic GaN-based heterostructure artificial synaptic device for associative learning and neuromorphic computing被引量：1
《Journal of Semiconductors》2025年第2期114-120,共7页Teng Zhan Jianwen Sun Jin Lin Banghong Zhang Guanwan Liao Zewen Liu Junxi Wang Jinmin Li Xiaoyan Yi 
supported by the National Key R&D Program of China(2021YFB3601000,2021YFB3601004);the National Key R&D Program of China(2022YFB3604702);the Chinese Academy of Sciences.
In recent years,research focusing on synaptic device based on phototransistors has provided a new method for asso-ciative learning and neuromorphic computing.A TiO_(2)/AlGaN/GaN heterostructure-based synaptic phototra...
关键词：GAN HETEROSTRUCTURE neuromorphic SYNAPTIC OPTOELECTRONIC phototransisitor pavlov 
Reconfigurable organic ambipolar optoelectronic synaptic transistor for information security access被引量：1
《Journal of Semiconductors》2025年第2期133-142,共10页Xinqi Ma Wenbin Zhang Qi Zheng Wenbiao Niu Zherui Zhao Kui Zhou Meng Zhang Shuangmei Xue Liangchao Guo Yan Yan Guanglong Ding Suting Han Vellaisamy A.L.Roy Ye Zhou 
the National Natural-Science Foundation of China(Grant No.62304137);Guangdong Basic and Applied Basic Research Foundation(Grant Nos.2023A1515012479,2024A1515011737,and 2024A1515010006);the Science and Technology Innovation Commission of Shenzhen(Grant No.JCYJ20220818100206013);RSC Researcher Collaborations Grant(Grant No.C23-2422436283);State Key Laboratory of Radio Frequency Heterogeneous Integration(Independent Scientific Research Program No.2024010);the Project on Frontier and Interdisciplinary Research Assessment,Academic Divisions of the Chinese Academy of Sciences(Grant No.XK2023XXA002);NTUT-SZU Joint Research Program.
In this data explosion era,ensuring the secure storage,access,and transmission of information is imperative,encom-passing all aspects ranging from safeguarding personal devices to formulating national information secu...
关键词：RECONFIGURABLE AMBIPOLAR OPTOELECTRONIC synaptic transistor light assisted burn after reading 
Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice
《Acta Pharmacologica Sinica》2025年第2期353-365,共13页Ya-nan Gao Kai-jun Pan Yong-mei Zhang Ying-bei Qi Wen-gang Chen Ting Zhou Hai-chao Zong Hao-ran Guo Jin-wen Zhao Xing-chen Liu Zi-tong Cao Ze Chen Tao Yin Yi Zang Jia Li 
founded by National Natural Science Foundation of China grant 82001572;National Natural Science Foundation of China grant 81971265;National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program”grant 2018ZX09711002-007-002;Shanghai Commission of Science and Technology grant 2021000003;Shanghai Science and Technology Development Funds(Shanghai Commission of Science and Technology)grant 19JC1416300.
Depressive disorders are a global mental health challenge that is closely linked to inflammation,especially in the post-COVID-19 era.The JAK-STAT pathway,which is primarily associated with inflammatory responses,is no...
关键词：tofacitinib depression JAK-STAT pathway MICROGLIOSIS synaptic defects 
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