Antarctic krill peptides improve scopolamine-induced memory impairment in mice  

作　　者：Jingru Zheng Yuanhong Gao Jie Ding Na Sun Songyi Lin 

机构地区：[1]National Engineering Research Center of Seafood,School of Food Science and Technology,Dalian Polytechnic University,Dalian,116034,PR China [2]Collaborative Innovation Center of Seafood Deep Processing,Dalian Polytechnic University,Dalian,116034,PR China

出　　处：《Food Bioscience》2022年第5期999-1009,共11页食品生物科学（英文）

基　　金：supported by National Natural Science Foundation of China[Grant No.32022067];Dalian Hih-level Talent Innovation Support Program of China[Grant No.2019RQ003].

摘　　要：The study aims to investigate the repair effects of Ser-Ser-Asp-Ala-Phe-Phe-Pro-Phe-Arg(SSDAFFPFR)and Ser-Asn-Val-Phe-Asp-Met-Phe(SNVFDMF)peptides on scopolamine-caused memory impairment in mice.Behavioral experiments have revealed that Antarctic krill peptides can ameliorate scopolamine caused memory impairment by changing the behavior of mice.In comparison with the scopolamine group,the two peptides at a dose of 40 mg/kg could improve memory impairment.The serum SOD activity(82.82±0.19 vs 79.47±2.42 U/mg prot)and hippocampal ACh level(101.46±3.23 vs 99.85±7.13μg/mg prot)of SSDAFFPFR were higher than those of SNVFDMF.Hippocampal AChE activity(0.20±0.03 vs 0.53±0.02 U/mg prot),hippocampal MDA level(1.56±0.01 vs 1.63±0.05 nmol/mg prot)and the serum MDA level(3.38±0.24 vs 3.88±0.21 nmol/mg prot)was lower than that of SNVFDMF.The state of mouse hippocampal cells was further observed by a microscopic imaging system.In addition,western blot analysis showed that SSDAFFPFR could significantly inhibit the expression of Bax,caspase-3,and p53,and promote the expression of BCL-XL,CREB,and BDNF,thus protecting hippocampal neurons in mice.In conclusion,the Antarctic krill peptide can repair scopolamine-induced memory impairment in mice.

关 键 词：Antarctic krill Bioactive peptide HIPPOCAMPUS Memory impairment Scopolamine mouse model Protein expression level 

分 类 号：TS201[轻工技术与工程—食品科学]