ANTICHOLINERGIC

作品数:13被引量:48H指数:3
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相关领域:医药卫生更多>>
相关作者:王茜方翼马秀英更多>>
相关机构:北京大学中国药学会军事医学科学院更多>>
相关期刊:《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《World Journal of Emergency Medicine》《中国临床药理学杂志》更多>>
相关基金:国家自然科学基金更多>>
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Beauty of the beast: anticholinergic tropane alkaloids in therapeutics被引量:3
《Natural Products and Bioprospecting》2022年第1期515-529,共15页Kyu Hwan Shim Min Ju Kang Niti Sharma Seong Soo A.An 
funded by the National Research Foundation of Korea and by the Korean Government (2020R1A2B5B01002463 and 2021R1A6A1A03038996).
Tropane alkaloids(TAs)are among the most valued chemical compounds known since pre-historic times.Poisonous plants from Solanaceae family(Hyoscyamus niger,Datura,Atropa belladonna,Scopolia lurida,Mandragora officinaru...
关键词:Tropane alkaloids Poisonous plants Anticholinergic action Muscarinic and nicotinic receptors THERAPEUTICS Anticholinergic burden 
Anticholinergic medications even in therapeutic range can cause recurrence of psychosis
《General Psychiatry》2020年第4期245-246,共2页Soumitra Das Seshadri Sekhar Chatterjee Barikar Chandrappa Malathesh 
Anticholinergic drugs are commonly used in psychiatry to attenuate antipsychotic induced extrapyramidal syndrome(EPS).Psychosis as a side effect is generally explained under the rubric of anticholinergic toxicity or i...
关键词:CHOLINERGIC drugs PRESCRIBED 
Antidiarrheal potential of Distemonanthus benthamianus Baillon. extracts via inhibiting voltage-dependent calcium channels and cholinergic receptors被引量:2
《Asian Pacific Journal of Tropical Biomedicine》2019年第11期449-455,共7页William Yousseu Nana Gilbert Ateufack Marius Mbiantcha Shamim Khan Hafiz Majid Rasheed AlbertAtsamo Abdul Jabbar Shah Albert Kamanyi Taous Khan 
supported by the CIIT-TWAS Sandwich Postgraduate Fellowship(FR number:3240293217,2016).
Objective:To evaluate spasmolytic mechanisms of aqueous and methanolic extracts from Distemonanthus benthamianus trunk-bark.Methods:Spasmolytic activities of extracts were evaluated in vitro on spontaneous and potassi...
关键词:Distemonanthus benthamianus HPLC Calcium-channels BLOCKING ANTICHOLINERGIC 
Suggested Two Hypotheses on Dementia (“Anticholinergic Hypothesis” and “Cranial Skeletal Muscles Hypothesis”) and the Therapeutic Agent
《Advances in Alzheimer's Disease》2019年第2期15-26,共12页Aibi Ivy Numazawa 
The present study was conducted with the objective of further developing the cholinergic hypothesis and not using the prevalent amyloid beta plaque hypothesis or the tau protein hypothesis on dementia. The experiment ...
关键词:DEMENTIA Alzheimer ANTICHOLINERGIC SCOPOLAMINE METHOCARBAMOL Ymaze Skeletal Muscles 
Anticholinergic syndrome induced by toxic plants被引量:1
《World Journal of Emergency Medicine》2017年第4期297-301,共5页Stergios Soulaidopoulos Emmanouil Sinakos Despoina Dimopoulou Christos Vettas Evangelos Cholongitas Alexandros Garyfallos 
Plant intoxication constitutes an issue of greatinterest in the literature, concerning both human andanimal poisoning. Different herbs may produce multipleeffects from human organ systems, depending on specifi cingred...
关键词:Anticholinergic syndrome toxic plants 
新型抗胆碱药物在慢性阻塞性肺疾病治疗中的研究状况被引量:14
《中国临床药理学杂志》2016年第10期949-951,960,共4页王艺曈 王茜 方翼 
近年来,慢性阻塞性肺疾病(COPD)发病率不断上升,病死率逐渐增加,严重威胁着全世界患者的生命健康。由于胆碱能神经及其受体的变化在COPD的发病过程中起重要的作用,因此抗胆碱药物是目前治疗COPD的主要药物之一。本文主要对已有的以及目...
关键词:chronic OBSTRUCTIVE PULMONARY disease MUSCARINIC receptor ANTICHOLINERGIC agents 
Evaluation of the efficacy and safety of tiotropium bromide (5 μg) inhaled via Respimat in Chinese patients with chronic obstructive pulmonary disease被引量:12
《Chinese Medical Journal》2013年第19期3603-3607,共5页TANG Yah Dan Massey ZHONG Nan-shan 
Background A pharmacokinetic study in an Asian population showed that tiotropium 5 μg via Respimat leads to the same plasma levels compared to 18 μg via HandiHaler.The objective of the trial was to compare the effic...
关键词:chronic obstructive pulmonary disease tiotropium bromide ANTICHOLINERGIC pulmonary function 
Unexpected anterograde amnesia associated with Buscopan used as a predmedication for endocscopy
《World Journal of Gastroenterology》2007年第28期3895-3896,共2页Hyuk Lee Hee Jung Son Poong-Lyul Rhee Jae J Kim Jong Chul Rhee 
It has been known that peripheral adverse event is caused by peripheral antimuscarinic action, from hyoscine butylbromide (Buscopan; Boehringer Ingelheim, Germany) used as a premedication for endoscopy. However, sympt...
关键词:ENDOSCOPY Hyoscine butylbromide Central anticholinergic syndrome AMNESIA 
Pharmacological profiles of an anticholinergic agent,phencynonate hydrochloride,and its optical isomers被引量:12
《Acta Pharmacologica Sinica》2005年第5期527-532,共6页Li-yunWANG YunWANG Jian-quanZHENG Bo-huaZHONG HeLIU Si-jianDONG Jin-xiuRUAN Ke-liangLIU 
Project supported by the Major Program of National Natural Science Foundation of China(№ 203900508)
Aim:To comparatively study the pharmacological profiles of 3-methyl-3-azabicyclo (3,3,1)nonanyl-9-α-yl-α-cyclopentyl-α-phenyl-α-glycolate(phencynonate hydrochloride,CPG),an anticholinergic agent,and its enantiomer...
关键词:optical isomers muscarinic acetylcholinic receptors pharmacological profiles radioligand binding assay 
THE PREPARATION AND BIOACTIVITIES OF OPTICALANALOGS OF BAOGONGTENG A被引量:2
《Medical Bulletin of Shanghai Jiaotong University》1999年第1期51-53,共3页杨丽敏 王惠宁 严忠红 
objective We prepared optical analogs of Baogongteng A and investigated their bioactivities soas to find new effective hypotoxic drugs at M- receptors. Methods Racemic analogs of Baogongteng A wereresolved with chiral...
关键词:ANALOGS of Baogongteng A CHIRAL MEDICINE ANTICHOLINERGIC ACTIVITY 
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