THE PREPARATION AND BIOACTIVITIES OF OPTICALANALOGS OF BAOGONGTENG A  

作　　者：杨丽敏 王惠宁 严忠红 

出　　处：《Medical Bulletin of Shanghai Jiaotong University》1999年第1期51-53,共3页上海交通大学学报（医学英文版）

摘　　要：objective We prepared optical analogs of Baogongteng A and investigated their bioactivities soas to find new effective hypotoxic drugs at M- receptors. Methods Racemic analogs of Baogongteng A wereresolved with chiral acid. Results Six chiral analogs of Baogongteng A were prepared. In mydriatic tests inrabbits, (+) - 32 - benzoyloxy - 6β - acetoxytropane and (+) - 32 - parachloro benzoyloxy- 6β- acetoxytropanepossess anticholinergic activities. Conclusion The configuration of enantiomers has significant influence on thebioactivity of analogs of Baogongteng A.objective We prepared optical analogs of Baogongteng A and investigated their bioactivities soas to find new effective hypotoxic drugs at M- receptors. Methods Racemic analogs of Baogongteng A wereresolved with chiral acid. Results Six chiral analogs of Baogongteng A were prepared. In mydriatic tests inrabbits, (+) - 32 - benzoyloxy - 6β - acetoxytropane and (+) - 32 - parachloro benzoyloxy- 6β- acetoxytropanepossess anticholinergic activities. Conclusion The configuration of enantiomers has significant influence on thebioactivity of analogs of Baogongteng A.

关 键 词：ANALOGS of Baogongteng A CHIRAL MEDICINE ANTICHOLINERGIC ACTIVITY 

分 类 号：R96[医药卫生—药理学]