MUSCARINIC

作品数：54被引量：199H指数：7
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相关领域：医药卫生更多>>
相关作者：张麟胡大一李静王昊刘洪瑞更多>>
相关机构：北京大学首都医科大学附属北京朝阳医院中国医科大学延边大学更多>>
相关期刊：《Science Bulletin》《Neuroscience Bulletin》《Journal of Traditional Chinese Medicine》《国际眼科杂志》更多>>
相关基金：国家自然科学基金霍英东教育基金国家重点基础研究发展计划苏州市科技计划项目更多>>
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Structure-activity relationship of pyrazol-4-ylpyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4
《Acta Pharmaceutica Sinica B》2023年第1期213-226,共14页Ahmed Haider Xiaoyun Deng Olivia Mastromihalis Stefanie K.Pfister Troels E.Jeppesen Zhiwei Xiao Vi Pham Shaofa Sun Jian Rong Chunyu Zhao Jiahui Chen Yinlong Li Theresa R.Connors April T.Davenport James B.Daunais Vahid Hosseini Wenqing Ran Arthur Christopoulos Lu Wang Celine Valant Steven H.Liang 
supported by the Swiss National Science Foundation(SNSF);supported by the National Health and Medical Research Council(NHMRC)Program Grant(APP1055134,USA);the Australian Research Council(ARC)Discovery Project(DP190102950,USA);supported by grants from Fulbright Denmark,The Lundbeck Foundation,Eva and Henry Frònkels foundation,The Danish Cancer Society,The Harboe Foundation。
There is an accumulating body of evidence implicating the muscarinic acetylcholine receptor4(M4)in schizophrenia and dementia with Lewy bodies,however,a clinically validated M4positron emission tomography(PET)radiolig...
关键词：Muscarinicacetylcholine receptor Positronemission tomography NEUROIMAGING NEUROPHARMACOLOGY Neurological disorders 
Beauty of the beast: anticholinergic tropane alkaloids in therapeutics被引量：3
《Natural Products and Bioprospecting》2022年第1期515-529,共15页Kyu Hwan Shim Min Ju Kang Niti Sharma Seong Soo A.An 
funded by the National Research Foundation of Korea and by the Korean Government (2020R1A2B5B01002463 and 2021R1A6A1A03038996).
Tropane alkaloids(TAs)are among the most valued chemical compounds known since pre-historic times.Poisonous plants from Solanaceae family(Hyoscyamus niger,Datura,Atropa belladonna,Scopolia lurida,Mandragora officinaru...
关键词：Tropane alkaloids Poisonous plants Anticholinergic action Muscarinic and nicotinic receptors THERAPEUTICS Anticholinergic burden 
M_(4) muscarinic receptors regulates dopamine/DARPP-32 signaling and glutamate transmis⁃sion to balance dopaminergic D1 function in mouse dorsal striatum
《中国药理学与毒理学杂志》2021年第9期689-689,共1页ZHOU Hu ZHANG Jing-xin LI Xing SHI Hua-xiang SUI Xin WANG Yong-an LI Jin WANG Li-yun 
OBJECTIVE Abnormal striatal dopaminergic and glutamatergic neurotransmis⁃sion is central to the pathophysiology of schizo⁃phrenia.In this study,we investigated the roles of M4 receptor interplay with D1 signaling in s...
关键词：dorsal striatum dopamine receptor 1 muscarinic acetylcholine M4 receptor dopamine-and cAMP-regulated phosphoprotein of 32 ku 
Dopaminergic-cholinergic imbalance in movement disorders: a role for the novel striatal dopamine D2-muscarinic acetylcholine M1 receptor heteromer
《Neural Regeneration Research》2021年第7期1406-1408,共3页RenéA.J.Crans Francisco Ciruela 
supported by the Fonds Wetenschappelijk Onderzoek(FWOSBO, Grant number 140028);Ministerio de Ciencia, Innovación y Universidades-Agencia Estatal de Investigación/FEDER(Grant number SAF2017-87349-R);Generalitat de Catalunya(Grant numbers 2017 SGR1604 and 2017 SGR595);Fundació la Marató de TV3(grant number 20152031);supported by an FWO Travel Grant for a Long Stay Abroad(grant number V420718N);an EMBO Short-Term Fellowship(grant number 6735)。
The striatum is the primary input structure of the basal ganglia, which participates in motivational and goaldirected behaviors(Pisani et al., 2007).In physiological conditions, local cholinergic interneurons(ChIs) an...
关键词：al. DOPAMINE DOPAMINE 
Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases被引量：7
《Neuroscience Bulletin》2019年第1期156-166,共11页Longzhu Liu Ming Zhao Xiaojiang Yu Weijin Zang 
supported by grants from the National Natural Science Foundation of China(81770293 and 81473203)
Cardiovascular diseases are life-threatening illnesses with high morbidity and mortality. Suppressed vagal(parasympathetic) activity and increased sympathetic activity are involved in these diseases. Currently, pharma...
关键词：Cardiovascular disease CHOLINERGIC DRUGS MUSCARINIC RECEPTOR a7-nACh RECEPTOR VAGUS nerve Vagomimetic DRUGS 
Effect of green flickering light on myopia development and expression of M1 muscarinic acetylcholine receptor in guinea pigs被引量：9
《International Journal of Ophthalmology(English edition)》2018年第11期1755-1760,共6页Yuan Tao Xiao-Li Li Li-Yuan Sun Yu-Hua Wei Xiao-Ting Yu Hong Wang 
Supported by Qilu Hospital of Shandong University (No.201805049)
AIM： To investigate the effects of green flickering light on refractive development and expression of muscarinic acetylcholine receptor（mAChR） M1 in the eyes of guinea pigs.METHODS： Thirty guinea pigs（15-20 days ...
关键词：guinea pigs green flashing light myopia model muscarinic acetylcholine RECEPTOR 
Cyclin-dependent kinase 5 is required for suppressing D1-dependent signaling mediated through muscarinic 4 in isolated medium spiny neurons
《中国药理学与毒理学杂志》2018年第9期689-690,共2页ZHOU Hu YANG Pei NIE Zhi-yong SHI Jing-shan WANG Li-yun LI Jin 
OBJECTIVE Previous studies have demonstrated acetylcholine muscarinic 4(M4) receptor regulates DARPP-32 phosphorylation at Thr75 in isolated medium spiny neurons(MSNs),indicating antagonistic mechanism with D1 depende...
关键词：ACETYLCHOLINE M4 RECEPTOR DOPAMINE D1 RECEPTOR DARPP32 PHOSPHORYLATION cyclin-dependent kinase 5 
Role of M<sub>3</sub>Muscarinic Acethylcholine Receptor Antibodies as a New Marker in Primary Sjögren Syndrome
《Pharmacology & Pharmacy》2017年第7期242-252,共11页Silvia Reina Cecilia Pisoni Roberto Arana Sabrina Ganzinelli Enri Borda 
Aims: This paper investigates the presence of M3 muscarinic acetylcholine receptor autoantibody present in the serum of patients with primary Sj?gren syndrome (pSS). Main methods: We detected the levels of M3mAChR pep...
关键词：Anti-Ro/SSA Antibody ANTI M3mAChR Peptide IgG IL-1β PGE2 NITRIC Oxide 
新型抗胆碱药物在慢性阻塞性肺疾病治疗中的研究状况被引量：14
《中国临床药理学杂志》2016年第10期949-951,960,共4页王艺曈 王茜 方翼 
近年来,慢性阻塞性肺疾病(COPD)发病率不断上升,病死率逐渐增加,严重威胁着全世界患者的生命健康。由于胆碱能神经及其受体的变化在COPD的发病过程中起重要的作用,因此抗胆碱药物是目前治疗COPD的主要药物之一。本文主要对已有的以及目...
关键词：chronic OBSTRUCTIVE PULMONARY disease MUSCARINIC receptor ANTICHOLINERGIC agents 
Allosteric modulation of cholinergic system:Potential approach to treating cognitive deficits of schizophrenia被引量：3
《World Journal of Pharmacology》2016年第1期32-43,共12页Shaun Hopper Madhara Udawela Elizabeth Scarr Brian Dean 
Schizophrenia is a psychiatric disorder affecting approximately 1% of the population worldwide and is characterised by the presence of positive and negative symptoms and cognitive deficits. Whilst current therapeutics...
关键词：Central nervous system ANTIPSYCHOTIC ALLOSTERIC CHOLINERGIC SCHIZOPHRENIA MUTAGENESIS Cognition MUSCARINIC 
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