BLOCKING

作品数：429被引量：1054H指数：14
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Efficient Production of Pyrrolnitrin by Optimizing Culture Medium and Blocking Competitive Secondary Metabolic Pathways in Pseudomonas protegens JP2-4390
《Rice science》2025年第2期156-159,I0033-I0040,共12页SHEN Jiamin ZHANG Xinxin WANG Yucong CHEN Guoqing FENG Guozhong 
supported by the Key Technology R&D Program of Zhejiang Province,China(Grant No.2021C02006).
Pyrrolnitrin(PRN),a natural halogenated phenylpyrrole derivative,exhibits a broad spectrum of antimicrobial activity against a wide range of bacteria and fungi.In this study,we isolated a strain of Pseudomonas protege...
关键词：DERIVATIVE SPECTRUM Efficient 
Deep Reinforcement Learning-based Multi-Objective Scheduling for Distributed Heterogeneous Hybrid Flow Shops with Blocking Constraints
《Engineering》2025年第3期278-291,共14页Xueyan Sun Weiming Shen Jiaxin Fan Birgit Vogel-Heuser Fandi Bi Chunjiang Zhang 
partially supported by the National Key Research and Development Program of the Ministry of Science and Technology of China(2022YFE0114200);the National Natural Science Foundation of China(U20A6004).
This paper investigates a distributed heterogeneous hybrid blocking flow-shop scheduling problem(DHHBFSP)designed to minimize the total tardiness and total energy consumption simultaneously,and proposes an improved pr...
关键词：Multi-objective Markov decision process Multi-agent deep reinforcement learning Proximal policy optimization Distributed hybrid flow-shop scheduling Blocking constraints 
An epH-driven DNA nanodevice for impeding metastasis in vivo by selectively blocking cell signaling
《National Science Review》2025年第3期255-266,共12页Kun Yuan Hong-Min Meng Hongzhi Sun Lingbo Qu Zhaohui Li Weihong Tan 
supported by the Natural Science Foundation of Henan(232300421021 and 242300421121);the National Natural Science Foundation of China(22374136,22274143);Henan Fundamental Research Leading Talent,and the National Key Research and Development Program(2023YFF0714402 and 2023YFF0714400).
Invasion and metastasis dominate tumor progression,causing a substantial proportion of cancer-related deaths.However,the efficacy of current antimetastatic treatments is hampered by the dearth of targeted therapeutics...
关键词：antimetastatic therapy cellular signaling blockade DNA nanodevice extracellular pH tailored bioregulation 
High quantum yield yellow emission carbon dots for the construction of blue light blocking films
《Chinese Chemical Letters》2025年第2期216-221,共6页Liwen Wang Boyang Wang Siyu Lu Shubo Lv Xiaoli Qu 
supported by Medical Science and Technology Research Project of Henan Province(Joint Construction Project)(No.LHGJ20200433);National Natural Science Foundation of China(No.52122308)。
White light illumination is essential in daily life,however,the substantial amount of blue light it contains can damage human eyes.Therefore,it is important to block this high-energy blue light to protect visual healt...
关键词：Carbon dots High quantum yield Controllable preparation Blue light blocking Composite film 
Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages
《Acta Pharmacologica Sinica》2025年第2期430-447,共18页Yi-ping You Liang Yan Hua-yu Ke Ya-ping Li Zi-jian Shi Zhi-ya Zhou Hai-yan Yang Tao Yuan Ying-qing Gan Na Lu Li-hui Xu Bo Hu Dong-yun Ou-Yang Qing-bing Zha Xian-hui He 
supported by the grants from the National Natural Science Foundation of China(82274167,81773965,and 81873064);the Science and Technology Project of Heyuan,China(Social Development and Rural Science No.2023008);the Project of Guangdong Administration of Traditional Chinese Medicine(20232177).
PANoptosis is an emerging form of regulated cell death(RCD)characterized by simultaneous activation of pyroptotic,apoptotic,and necroptotic signaling that not only participates in pathologies of inflammatory diseases ...
关键词：MACROPHAGES PANoptosis BAICALIN mitochondrial Z-DNA ZBP1 hemophagocytic lymphohistiocytosis 
Ligustroside derived from Ligustrum japonicum inhibits melanogenesis via blocking the MAPK and PKA/CREB signaling pathways
《Asian Pacific Journal of Tropical Biomedicine》2025年第2期65-74,I0004,I0005,共12页Xian-Rong Zhou Fatih Karadeniz Jung Hwan Oh Youngwan Seo Chang-Suk Kong 
supported by the BB21plus funded by Busan Metropolitan City and Busan Techno Park,and the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.NRF-2023R1A2C1006268 and RS-2023-00212560).
Objective:To investigate the anti-melanogenic potential of ligustroside isolated from Ligustrum japonicum.Methods:The cytotoxicity of ligustroside was tested via MTT assay.Furthermore,the effects of ligustroside on th...
关键词：Ligustrum japonicum Ligustroside MAPK MELANOGENESIS CREB PKA 
Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2
《Science China(Life Sciences)》2025年第1期189-203,共15页Wenjie Li Wenyi Mei Hewei Jiang Jie Wang Xiaoli Li Lina Quan Yanyan Diao Yanni Ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi Feng Zhang Lei Ma Jian Zhang Yufeng Gao Aris Paschalidis Honghuang Lin Fangfang Liu Kangdong Liu Mingliang Ye Zhenjiang Zhao Yajun Duan Zhuo Chen Yufang Xu Weilie Xiao Shengce Tao Lili Zhu Honglin Li 
supported in part by the National Natural Science Foundation of China (81825020, 82150208, 82260682);the National Key R&D Program of China (2022YFC3400501, 2022YFC3400504);the Shanghai Science and Technology Commission Biomedical Science and Technology Support Special Project (21S11907900, 20S11901000);Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform (2022YKZY001);sponsored by the National Program for Special Supports of Eminent Professionals;National Program for Support of Top-notch Young Professionals
Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for immunotherapy.Here,we identify a natural pentacyclic triterpenoid,Pygenic Acid A(PA),as a PD-1 signaling inhibitor.PA exerts an...
关键词：pygenic acid A programmed death-1 immunoreceptor tyrosine-based switch motif SH2 domain-containing protein-tyrosine phosphatase-2 target identification site recognition 
Synthesis of an AVB@ZnTi-LDH composite with synergistically enhance UV blocking activity and high stability for potential application in sunscreen formulations
《Chinese Chemical Letters》2024年第11期559-564,共6页Xiaomeng Hu Jie Yu Lijie Sun Linfeng Zhang Wei Zhou Dongpeng Yan Xinrui Wang 
supported by the China Scholarship Council(No.202308110152)。
1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione(known as Avobenzone/AVB),widely used throughout the world as a highly effective UVA absorber,can prevent the progression of photoaging in skin,and i...
关键词：Avobenzone Layered double hydroxide UV resistance SUNSCREEN BIOCOMPATIBILITY 
Huaiyu pill(槐榆片)alleviates inflammatory bowel disease in mice via blocking toll like receptor 4/myeloid differentiation primary response gene 88/nuclear factor kappa B subunit 1 pathway被引量：1
《Journal of Traditional Chinese Medicine》2024年第5期916-925,共10页YANG Chunyan LUO Jia PENG Weijie DAI Weibo 
the Medical Scientific Research Foundation of Guangdong Province of China:Mechanistic Study on the Regulation of Mucin 2/interleukin 6-signal Transducer and Activator of Transcription 3 Signaling Pathway by Active Saponin Ardisiacrispin B in Improving Ulcerative Colitis Intestinal Mucosal Barrier Dysfunction(A2022479);the Guangdong Provincial Basic and Applied Basic Research Project:Mechanistic Study on the Regulation of Inflammatory Microenvironment and Improvement of Ulcerative Colitis by Lingnan Traditional Medicine Ficus Quercifolia through Wilms'tumor 1-associating Protein-Mediated RNA Methyltransferase Promoting Toll Like Receptor 4 m6A Modification(2023A1515011699)。
OBJECTIVE:To investigate the therapeutic effects of Huaiyu pill(槐榆片,HYP)on inflammatory bowel disease(IBD)and the underlying mechanisms have not been elucidated.METHODS:To establish the IBD model,mice were administ...
关键词：inflammatory bowel diseases network pharmacology intestinal inflammation intestinal damage Huaiyu pill 
“Blocking and rebalance”mechanism-guided design strategies of bimetallic doped 2D a-phosphorus carbide as efficient catalysts for N_(2) electroreduction
《Journal of Energy Chemistry》2024年第10期68-78,I0003,共12页Cheng He Jianglong Ma Shen Xi Wenxue Zhang 
supports by the National Natural Science Foundation of China (NSFC,Grant No.52271113);the Natural Science Foundation of Shaanxi Province,China (2020JM-218);the Fundamental Research Funds for the Central Universities (CHD300102311405);HPC platform,Xi’an Jiaotong University。
Compared to single atom catalysts(SACs),the introduction of dual atom catalysts(DACs)has a significantly positive effect on improving the efficiency in the electrocatalytic nitrogen reduction reaction(NRR)which provid...
关键词：DACs Nitrogen reduction reaction 2D a-phosphorus carbide Inherent attributes Machine learning 
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