BLOCKING

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High quantum yield yellow emission carbon dots for the construction of blue light blocking films
《Chinese Chemical Letters》2025年第2期216-221,共6页Liwen Wang Boyang Wang Siyu Lu Shubo Lv Xiaoli Qu 
supported by Medical Science and Technology Research Project of Henan Province(Joint Construction Project)(No.LHGJ20200433);National Natural Science Foundation of China(No.52122308)。
White light illumination is essential in daily life,however,the substantial amount of blue light it contains can damage human eyes.Therefore,it is important to block this high-energy blue light to protect visual healt...
关键词：Carbon dots High quantum yield Controllable preparation Blue light blocking Composite film 
Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages
《Acta Pharmacologica Sinica》2025年第2期430-447,共18页Yi-ping You Liang Yan Hua-yu Ke Ya-ping Li Zi-jian Shi Zhi-ya Zhou Hai-yan Yang Tao Yuan Ying-qing Gan Na Lu Li-hui Xu Bo Hu Dong-yun Ou-Yang Qing-bing Zha Xian-hui He 
supported by the grants from the National Natural Science Foundation of China(82274167,81773965,and 81873064);the Science and Technology Project of Heyuan,China(Social Development and Rural Science No.2023008);the Project of Guangdong Administration of Traditional Chinese Medicine(20232177).
PANoptosis is an emerging form of regulated cell death(RCD)characterized by simultaneous activation of pyroptotic,apoptotic,and necroptotic signaling that not only participates in pathologies of inflammatory diseases ...
关键词：MACROPHAGES PANoptosis BAICALIN mitochondrial Z-DNA ZBP1 hemophagocytic lymphohistiocytosis 
Ligustroside derived from Ligustrum japonicum inhibits melanogenesis via blocking the MAPK and PKA/CREB signaling pathways
《Asian Pacific Journal of Tropical Biomedicine》2025年第2期65-74,I0004,I0005,共12页Xian-Rong Zhou Fatih Karadeniz Jung Hwan Oh Youngwan Seo Chang-Suk Kong 
supported by the BB21plus funded by Busan Metropolitan City and Busan Techno Park,and the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.NRF-2023R1A2C1006268 and RS-2023-00212560).
Objective:To investigate the anti-melanogenic potential of ligustroside isolated from Ligustrum japonicum.Methods:The cytotoxicity of ligustroside was tested via MTT assay.Furthermore,the effects of ligustroside on th...
关键词：Ligustrum japonicum Ligustroside MAPK MELANOGENESIS CREB PKA 
Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2
《Science China(Life Sciences)》2025年第1期189-203,共15页Wenjie Li Wenyi Mei Hewei Jiang Jie Wang Xiaoli Li Lina Quan Yanyan Diao Yanni Ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi Feng Zhang Lei Ma Jian Zhang Yufeng Gao Aris Paschalidis Honghuang Lin Fangfang Liu Kangdong Liu Mingliang Ye Zhenjiang Zhao Yajun Duan Zhuo Chen Yufang Xu Weilie Xiao Shengce Tao Lili Zhu Honglin Li 
supported in part by the National Natural Science Foundation of China (81825020, 82150208, 82260682);the National Key R&D Program of China (2022YFC3400501, 2022YFC3400504);the Shanghai Science and Technology Commission Biomedical Science and Technology Support Special Project (21S11907900, 20S11901000);Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform (2022YKZY001);sponsored by the National Program for Special Supports of Eminent Professionals;National Program for Support of Top-notch Young Professionals
Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for immunotherapy.Here,we identify a natural pentacyclic triterpenoid,Pygenic Acid A(PA),as a PD-1 signaling inhibitor.PA exerts an...
关键词：pygenic acid A programmed death-1 immunoreceptor tyrosine-based switch motif SH2 domain-containing protein-tyrosine phosphatase-2 target identification site recognition 
Synthesis of an AVB@ZnTi-LDH composite with synergistically enhance UV blocking activity and high stability for potential application in sunscreen formulations
《Chinese Chemical Letters》2024年第11期559-564,共6页Xiaomeng Hu Jie Yu Lijie Sun Linfeng Zhang Wei Zhou Dongpeng Yan Xinrui Wang 
supported by the China Scholarship Council(No.202308110152)。
1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione(known as Avobenzone/AVB),widely used throughout the world as a highly effective UVA absorber,can prevent the progression of photoaging in skin,and i...
关键词：Avobenzone Layered double hydroxide UV resistance SUNSCREEN BIOCOMPATIBILITY 
Huaiyu pill(槐榆片)alleviates inflammatory bowel disease in mice via blocking toll like receptor 4/myeloid differentiation primary response gene 88/nuclear factor kappa B subunit 1 pathway被引量：1
《Journal of Traditional Chinese Medicine》2024年第5期916-925,共10页YANG Chunyan LUO Jia PENG Weijie DAI Weibo 
the Medical Scientific Research Foundation of Guangdong Province of China:Mechanistic Study on the Regulation of Mucin 2/interleukin 6-signal Transducer and Activator of Transcription 3 Signaling Pathway by Active Saponin Ardisiacrispin B in Improving Ulcerative Colitis Intestinal Mucosal Barrier Dysfunction(A2022479);the Guangdong Provincial Basic and Applied Basic Research Project:Mechanistic Study on the Regulation of Inflammatory Microenvironment and Improvement of Ulcerative Colitis by Lingnan Traditional Medicine Ficus Quercifolia through Wilms'tumor 1-associating Protein-Mediated RNA Methyltransferase Promoting Toll Like Receptor 4 m6A Modification(2023A1515011699)。
OBJECTIVE:To investigate the therapeutic effects of Huaiyu pill(槐榆片,HYP)on inflammatory bowel disease(IBD)and the underlying mechanisms have not been elucidated.METHODS:To establish the IBD model,mice were administ...
关键词：inflammatory bowel diseases network pharmacology intestinal inflammation intestinal damage Huaiyu pill 
“Blocking and rebalance”mechanism-guided design strategies of bimetallic doped 2D a-phosphorus carbide as efficient catalysts for N_(2) electroreduction
《Journal of Energy Chemistry》2024年第10期68-78,I0003,共12页Cheng He Jianglong Ma Shen Xi Wenxue Zhang 
supports by the National Natural Science Foundation of China (NSFC,Grant No.52271113);the Natural Science Foundation of Shaanxi Province,China (2020JM-218);the Fundamental Research Funds for the Central Universities (CHD300102311405);HPC platform,Xi’an Jiaotong University。
Compared to single atom catalysts(SACs),the introduction of dual atom catalysts(DACs)has a significantly positive effect on improving the efficiency in the electrocatalytic nitrogen reduction reaction(NRR)which provid...
关键词：DACs Nitrogen reduction reaction 2D a-phosphorus carbide Inherent attributes Machine learning 
An STP look at logical blocking of finite state machines: formulation, detection, and search被引量：1
《Science China(Information Sciences)》2024年第10期328-338,共11页Yongyi YAN Penglei HAO Jumei YUE Haitao LI Jun-E FENG 
supported in part by the National Natural Science Foundation of China (Grant Nos. U1804150, 62073124)。
The logical blocking of finite state machines(FSMs) is examined at the three levels of formulation,detection, and search from an STP viewpoint(semi-tensor product of matrices). The research idea regards an FSM as a lo...
关键词：semi-tensor product of matrices STP matrix approach finite-valued systems logical systems logical networks finite state machines 
Thyristor-inserted MMC Sub-module Topology with DC Fault Blocking Capability
《CSEE Journal of Power and Energy Systems》2024年第5期2221-2229,共9页Cheng Peng Rui Li Xu Cai 
supported by the National Key R&D Program of China(2018YFB1500702);the National Natural Science Foundation of China(52177187).
Modular multilevel converter(MMC)is increasingly being applied to high voltage direct current(HVDC)systems.However,dc short circuit situations restrain the application of a conventional half bridge MMC system.In this ...
关键词：Fault current limiting high voltage direct current(HVDC)transmission modular multilevel converter(MMC) 
Structural characteristics of phenylboronic acid-modified astaxanthin ester and its effect on DSS-induced ulcerative colitis by blocking reactive oxygen species and maintaining intestinal homeostasis
《Food Science and Human Wellness》2024年第5期2754-2764,共11页Xing Qiao Hongyan Li Qun Gao Zhigao Wang Jie Xu Lu Yang Changhu Xue 
provided by the National Key R&D Program of China(2018YFC0311206);the Fundamental Research Funds for the Central Universities of China(202012018).
A novel and reactive oxygen species(ROS)responsive astaxanthin phenylboronic acid derivative(AstaDPBA)was constructed by grafting phenylboronic acid(PBA)onto astaxanthin succinate diester(AstaD),and its chemical struc...
关键词：Astaxanthin ester Reactive oxygen species-responsive Ulcerative colitis Intestinal microbiota Inflammatory cytokines 
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