肺癌患者外周血淋巴细胞亚群水平的表达及临床意义  

Expression and Clinical Significance of Peripheral Blood Lymphocyte Subsets in Patients with Lung Cancer

作　　者：罗劼妍 黄浩[1] 黄胜兰[1] 陈炎[1] 陈洁[2] LUO Jie-yan, HUANG Hao1, HUANG Sheng-lan, CHEN Yen1, CHEN Jie2(1 First Department of Ontology, The Second People＇s Hospital of Yibin, Yibin, Sichuan, 644000, China; 2 Second Department of Oncology, The Second People＇s Hospital ofYibin, Yibin, Sichuan, 644000, Chin)

机构地区：[1]宜宾市第二人民医院肿瘤一科,四川宜宾644000 [2]宜宾市第二人民医院肿瘤二科,四川宜宾644000

出　　处：《现代生物医学进展》2018年第2期326-329,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨肺癌患者外周血淋巴细胞亚群水平的表达及临床意义。方法:选择2016年3月~2017年3月期间我院收治的88例肺癌患者作为研究组,选择同期于我院进行健康体检的88例受检者作为对照组。两组研究对象均通过流式细胞仪检测外周血T淋巴细胞亚群水平。观察对比两组研究对象外周血T淋巴细胞亚群的表达水平,以及研究组不同临床病理特征患者外周血T淋巴细胞亚群的表达水平。结果:研究组CD4^+/CD8^+、CD4^+、CD3^+表达水平均低于对照组,CD8^+表达水平高于对照组,差异具有统计学意义(P<0.05)。研究组Ⅲ期与Ⅳ期患者CD4^+/CD8^+、CD4^+、CD3^+表达水平均低于Ⅰ期与Ⅱ期,Ⅲ期与Ⅳ期患者CD8^+表达水平高于Ⅰ期与Ⅱ期(P<0.05);小细胞肺癌患者CD4^+/CD8^+、CD4^+、CD3^+表达水平均低于非小细胞肺癌患者,CD8^+表达水平高于非小细胞肺癌患者,差异具有统计学意义(P<0.05)。不同性别、年龄、肿瘤分化程度肺癌患者CD4^+/CD8^+、CD8^+、CD4^+、CD3^+水平无统计学差异(P>0.05)。结论:肺癌患者外周血淋巴细胞亚群水平的表达呈现异常状态,且表达水平与疾病的分期和病理分型有关。Objective： To investigate the expression and clinical significance of peripheral blood lymphocyte subsets in patients with lung cancer. Methods： A total of 88 patients with lung cancer,who were admitted to Second People＇s Hospital of Yibin from March2016 to March 2017, were chosen as study group; 88 subjects, who underwent physical examination in the hospital during the same period, were chosen as control group.The peripheral blood T lymphocyte subsets of the patients of the two groups were detected by flow cytometry. The expression levels of peripheral blood T lymphocyte subsets of the patients in the two groups were observed and compared, and the expression levels of peripheral blood T lymphocyte subsets of the patients with different clinicopathological characteristics in the study group were analyzed. Results： The expression levels of CD4~＋/CD8~＋, CD4~＋and CD3~＋in the study group were lower than those in the control group, the expression level of CD8~＋was higher than that in the control group, the difference was statistically significant（P0.05）. The expression levels of CD4~＋/CD8~＋, CD4~＋and CD3~＋of the patients of the study group in stage III and IV were lower than those in stage I and II, and the expression level of CD8~＋in stage III and IV was higher than that in stage I and II（P0.05）. The expression levels of CD4~＋/CD8~＋, CD4~＋and CD3~＋in the patients with small cell lung cancer were lower than those in the patients with non-small cell lung cancer, the expression level of CD8~＋was higher than that in the patients with non-small cell lung cancer,the difference was statistically significant（P0.05）. There were no significant differences in the levels of CD4~＋/CD8~＋, CD4~＋and CD3~＋among the patients with different gender, age and tumor differentiation（P0.05）. Conclusion： The expression of peripheral blood lymphocyte subsets in the patients with lung cancer is abnormal,and the expression level is related to the stage and pathological type of lung

关 键 词：肺癌 外周血淋巴细胞亚群 表达 临床意义 

分 类 号：R734.2[医药卫生—肿瘤]