载脂蛋白E基因多态性与阿尔茨海默病相关性的Meta分析  

Association between apolipoproteins E gene polymorphism and Alzheimer disease: a Meta-analysis

作　　者：程蕊[1] 李玺[1] 王娟 权乾坤[1] 冯建军[1] CHENG Rui, LI Xi, QUAN Qian-kun, FENG Jian-jun.(Department of Geriatrics, the Second Affiliated Hospital of Xi ＇an Jiaotong University, Xi ＇an 710004, China ;） WANG Juan. （Department of Clinical Labora- tory, the First Affiliated Hospital of Fourth Military Medical University, Xi＇an 710032, China)

机构地区：[1]西安交通大学第二附属医院老年病科,陕西省西安市710004 [2]第四军医大学第一附属医院检验科,陕西省西安市710032

出　　处：《实用老年医学》2018年第3期263-267,共5页Practical Geriatrics

基　　金：陕西省自然科学基础研究计划-青年项目(2017JQ8039)

摘　　要：目的系统评价载脂蛋白E(Apo E)基因多态性与阿尔茨海默病(AD)的相关性。方法计算机检索Pubmed,Wiley Online Library,Springer Link,The Cochrane Library,中国知网,维普,万方全文数据库,收集国内外1990年1月至2016年1月发表的相关文献。制定文献纳入与排除标准,采用NOS量表评价纳入研究方法学质量,提取符合纳入标准的数据。应用Rev Man 5.3软件和Stata12.0软件进行Meta分析。结果共纳入19项研究,AD组4203例,对照组5081例。结果显示Apo Eε4等位基因或ε4/ε4、ε2/ε4、ε3/ε4基因型携带者AD易感性升高,Apo Eε2、ε3等位基因或ε2/ε2、ε3/ε3、ε2/ε3基因型携带者AD易感性降低,差异均有统计学意义(P<0.05)。结论 Apo E基因多态性与AD的发生密切相关。Apo Eε4等位基因及ε4/ε4、ε2/ε4、ε3/ε4基因型是AD发病危险因素,Apo Eε2、ε3等位基因及ε2/ε2、ε3/ε3、ε2/ε3基因型是AD发病的保护因素。Objective To systemically evaluate the relationship between apolipoproteins E（ Apo E）gene polymorphism and Alzheimer disease（ AD）.Methods Pubmed,Wiley Online Library,Springer Link,The Cochrane Library,Chinese CNKI Database,VIP Journals Database（ VIP） and Wanfang Fulltext Database were searched and the related literatures published from January 1990 to January 2016 were collected.The inclusion and exclusion standard was adopted,and the methodological quality of included studies was evaluated with the Newcastle-Ottawa Scale.Rev Man 5.3 software and Stata 12.0 software were used for making the Meta-analysis.Results Totally 19 studies were enrolled,with 4203 cases in AD group,5081 cases in control group.The results showed that individuals with Apo E ε4 allele or ε4/ε4,ε2/ε4,ε3/ε4 genotypes presented with higher risk for AD and individuals with Apo E ε2,ε3 alleles orε2/ε2,ε3/ε3,ε2/ε3 genotypes presented with lower risk for AD（ P〈 0.05）.Conclusions Apo E gene polymorphism is closely associated with the occurrence of AD.Apo E ε4 allele and ε4/ε4,ε2/ε4,ε3/ε4 genotypes are risk factors for AD.Apo E ε2,ε3 alleles and ε2/ε2,ε3/ε3,ε2/ε3 genotypes are protective factors for AD.

关 键 词：阿尔茨海默病 载脂蛋白E 基因多态性 病例对照研究 META分析 

分 类 号：R749.1[医药卫生—神经病学与精神病学]