509例子宫发育异常患者染色体核型分析  

Relationshipe of uterine dysplasia and chromosome karyotype in 509 examples

作　　者：杨文霞 高瑞宏 覃磊 王德堂 陈必良 张建芳 YANG Wen-xia, GAO Rui- hong, TAN Lei, WANG De-tang, CHEN Bi-liang, ZHANG Jian-fang(The First Affiliated Hospital, Air Force Medical University, Dipart. of Gynicol. ＆ Obsti. Xian, 71003)

机构地区：[1]空军军医大学第一附属医院妇产科,西安710032

出　　处：《中国优生与遗传杂志》2018年第3期33-34,45,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的通过细胞遗传学研究,探讨子宫发育异常与染色体核型的关系。方法取患者的外周血进行无菌培养、制片及G显带技术进行染色体核型分析。结果通过对509例患者核型分析,发现染色体异常59例(11.59%),其中先天性无子宫患者染色体异常率为11.70%(20/171);始基子宫患者染色体异常率为14.10%(11/78);幼稚子宫患者染色体异常率为10.77%(28/260)。59例染色体异常的患者中,X染色体数目异常占50.85%,X染色体结构异常占16.95%,常染色体异常占3.39%,含Y染色体占28.81%。结论 X染色体数目异常是导致子宫发育异常的主要原因之一。Objective：Through the cytogenetics research,discussing the relationship between uterine dysplasia and chromosome karyotype. Methods：Cultivate lymphocyte in peripheral blood in nutritive medium,analyze the karyotype using G band. Results：Through the karyotype analysis of 509 patients,found that chromosome abnormality 59 patients（11.59%）,chromosome abnormality rate was 11.70%（20/171）in patients with congenital no uterus;chromosome abnormality rate was 14.10%（11/78）in patients with primordium uterus;chromosome abnormality rate was 10.77%（28/260）in patients with childish uterus. 58 cases of chromosomal abnormalities in patients,X chromosome number abnormality（50.85%）,X chromosome structural abnormalities（16.95%）,autosomal abnormalities（3.39%）,containing Y chromosome 28.81%. Conclusion：X chromosome number abnormality is one of the main causes of uterine dysplasia.

关 键 词：染色体核型分析 先天性无子宫 始基子宫 幼稚子宫 

分 类 号：R596.1[医药卫生—内科学]