NAFLD患者肠粘膜机械屏障损伤的研究  

Study on Intestinal Mechanical Barrier Injury in Patients with NAFLD

作　　者：叶艳伟 庄丽维[1] 韩继武[1] 薄挽澜[1] 王立国[1] 李春苗[1] YE Yan-wei, ZHUANG Li-wei, HAN Ji-wu, BO Wan-lan, WANG Li-guo, LI Chun-miao(The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, 150000, Chin)

机构地区：[1]哈尔滨医科大学附属第四医院,黑龙江哈尔滨150000

出　　处：《现代生物医学进展》2018年第3期597-600,共4页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金项目(D201139)

摘　　要：非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是慢性肝损伤的主要病因之一。据估计,大约有20%的成人有非酒精性脂肪性肝病,2%-3%发展成非酒精性脂肪性肝炎(nonalcoholic steatohepatitis,NASH)。NASH是NAFLD的渐进形式,并可能导致肝硬化和肝细胞癌。NAFLD不仅增加了肝病患者死亡率,作为代谢综合征,还增加了肥胖、2型糖尿病及高脂血症的发病率。肌球蛋白轻链激酶(MLCK)是细胞收缩的关键酶,可使肌球蛋白轻链磷酸化(MLC),促使肌动蛋白收缩,破坏细胞间的紧密连接蛋白,使细胞骨架收缩,进而使肠上皮通透性增加,肠粘膜机械屏障遭到破坏,致使NAFLD的病情进一步发展。MLCK在NAFLD的发生及发展中起着重要作用。NAFLD严重威胁人类健康,影响人们的生活质量及生存质量。为NAFLD患者寻找崭新的治疗方法是极其必要的。Nonalcoholic fatty liver disease（NAFLD） is one of major causes of chronic liver injury. It is estimated that about 20 percent of adults have nonalcoholic fatty liver disease, 2%-3% developed into nonalcoholic steatohepatitis（NASH）. NASH is a progressive form of NAFLD, and may lead to cirrhosis and hepatocellular carcinoma. NAFLD not only increased the mortality of liver disease,as the metabolic syndrome, also increased obesity, type 2 diabetes and hyperlipidemia incidence. Myosin light chain kinase（MLCK） is a key enzyme in cell contraction, and it can phosphorylate myosin light chain（MLC）, promote actin to contract, disrupt the closely linked proteins, make the cell skeleton shrink, increase the permeability of the intestinal epithelium, destroy the intestinal mechanical barrier,and result in the further development of NAFLD. MLCK plays an important role in the occurrence and development of NAFLD. NAFLD seriously threatens the human health, and affects people＇s quality of life and survival quality. So it is extremely necessary to find a new trerapy for the patients with NAFLD.

关 键 词：非酒精性脂肪性肝病 肠粘膜机械屏障 肌球蛋白轻链激酶 紧密连接蛋白 

分 类 号：R575.5[医药卫生—消化系统]