子宫平滑肌瘤与乳腺癌发病及预后关系研究  

Relationship between uterine smooth muscle tumors and the incidence and prognosis of breast cancer

作　　者：邵燕霞[1] SHAO Yan-xia(Department of Obstetrics and Gynecology, The First People＇s Hospital of Neijiang , Sichuan Neijiang 641000, Chin)

机构地区：[1]内江市第一人民医院妇产科,四川内江641000

出　　处：《中国妇幼健康研究》2018年第3期317-320,共4页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨子宫平滑肌瘤与乳腺癌发病及预后的关系。方法回顾性分析2011年3月至2012年4月期间就诊内江市第一人民医院经确诊为子宫平滑肌瘤的患者共114例,其中合并有乳腺癌的患者有66例,无乳腺癌患者有48例,比较子宫平滑肌瘤与乳腺癌发病及生存率的关系,利用Logistic回归分析影响乳腺癌发病的危险因素,Cox回归模型分析乳腺癌预后的影响因素。结果乳腺癌组与无乳腺癌组在发病年龄、子宫肌瘤大小、位置、数目、是否良性方面均存在显著差异(χ~2值分别为5.037、4.930、5.879、3.042、4.154,均P<0.05),经单因素分析发现患者发病年龄、子宫肌瘤指标(大小和位置)、数目、是否良性在乳腺癌组3年、5年生存率间存在显著差异(χ~2=5.003~6.426,均P<0.05),经多元Logistic回归分析后得出子宫肌瘤位置、数目、是否良性是影响子宫肌瘤发生乳腺癌的独立危险因素(OR值分别为3.062、2.335、1.514,均P<0.05),Cox模型分析结果显示,肌瘤良恶性状态、子宫平滑肌瘤数目是影响乳腺癌组预后的因素(HR值分别为1.063、2.014,均P<0.05)。结论子宫平滑肌瘤是乳腺癌发病的影响因素,并且子宫平滑肌瘤数目和是否良性是乳腺癌的预后影响因素。Objective To investigate the relationship between uterine smooth muscle tumors （USMT） and the incidence and prognosis of breast cancer. Methods Retrospective analysis was performed on 114 cases of USMT diagnosed in the First People＇s Hospital of Neijiang from March 2011 to April 2012, among whom there were 66 cases accompanied with breast cancer and 48 cases without breast cancer. The relationship between USMT and the incidence and survival rate of breast cancer was analyzed. Analysis of risk factors for breast cancer was conducted with Logistic regression analysis and the prognostic factors of breast cancer with Cox regression model Results There were significant differences in onset age, size, location and number of uterine fibroids as well as whether they were benign between breast cancer group and non breast cancer group （χ^2 value was 5.037, 4.930, 5.879, 3.042 and 4.154, respectively, all P〈0.05）. Univariate analysis showed that there were significant differences in onset age, size, location and number of uterine fibroids as well as whether they were benign between survival rates of 3- and 5-year in breast cancer group （χ^2 value ranged 5.003-6.426, all P〈0.05）. Multivariate Logistic regression analysis revealed that the position, number and the characteristic of uterine myoma were independent risk factors affecting the occurrence of breast cancer in uterus myoma （OR value was 3.062, 2.335 and 1.514, respectively, all P〈0.05）. The Cox model analysis showed that the characteristic of tumor and the number of uterine leiomyoma were the factors affecting the prognosis of breast cancer （HR value was 1. 063 and 2.014, respectively, both P〈0.05）. Conclusion USMT is an influencing factor of breast cancer, and the number and whether uterine fibroids are benign are the prognostic factors of breast cancer.

关 键 词：子宫平滑肌瘤 乳腺癌 预后 发病 

分 类 号：R737.3[医药卫生—肿瘤]