Volumetric Changes in Hippocampal Subregions and Memory Performance in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis  被引量:6

Volumetric Changes in Hippocampal Subregions and Memory Performance in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

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作  者:Caihong Ji Lujia Zhu Cong Chen Shuang Wang Leilei Zheng Hong Li 

机构地区:[1]Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University [2]Department of Psychology, Second Affiliated Hospital,School of Medicine, Zhejiang University [3]Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University

出  处:《Neuroscience Bulletin》2018年第2期389-396,共8页神经科学通报(英文版)

基  金:supported by the National Natural Science Foundation of China(81271435 and 81671282)

摘  要:In the present study we explored the different patterns of volumetric atrophy in hippocampal subregions of patients with left and right mesial temporal lobe epilepsy with hippocampal sclerosis(TLE-HS). Meanwhile, the memory impairment patterns in Chinese-speaking TLE-HS patients and potential influencing factors were also determined. TLE-HS patients(21 left and 17 right) and 21 healthy controls were recruited to complete T2-weighted imaging and verbal/nonverbal memory assessment. The results showed that both left and right TLE-HS patients had overall reduced hippocampal subregion volumes on the sclerotic side, and cornu ammonis sectors(CA1) exhibited maximum atrophy. The verbal memory of left TLE-HS patients was significantly impaired(P \ 0.001) and was not associated with the volumes of the left hippocampal subregions. Verbal or nonverbal memory impairment was not found in the patients with right TLE-HS. These results suggested that the atrophy of hippocampal subregion volumes cannot account for the verbal memory impairment, which might be related to the functional network.In the present study we explored the different patterns of volumetric atrophy in hippocampal subregions of patients with left and right mesial temporal lobe epilepsy with hippocampal sclerosis(TLE-HS). Meanwhile, the memory impairment patterns in Chinese-speaking TLE-HS patients and potential influencing factors were also determined. TLE-HS patients(21 left and 17 right) and 21 healthy controls were recruited to complete T2-weighted imaging and verbal/nonverbal memory assessment. The results showed that both left and right TLE-HS patients had overall reduced hippocampal subregion volumes on the sclerotic side, and cornu ammonis sectors(CA1) exhibited maximum atrophy. The verbal memory of left TLE-HS patients was significantly impaired(P \ 0.001) and was not associated with the volumes of the left hippocampal subregions. Verbal or nonverbal memory impairment was not found in the patients with right TLE-HS. These results suggested that the atrophy of hippocampal subregion volumes cannot account for the verbal memory impairment, which might be related to the functional network.

分 类 号:R[医药卫生]

 

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