肺腺癌患者血清中lncRNA SFTA1P的表达及其诊断价值  

Expression and diagnostic value of lncRNA SFTA1P in serum of lung adenocarcinoma patients

作　　者：陈静静[1] 赵连爽[1] 代娣[1] 郭晓临[1] CHEN Jing-jing, ZHAO Lian-shuang, DAI Di, GUO Xiao-lin(Department of Clinical Laboratory Medicine, the First Hospital, China Medical University, Shenyang 110001, Chin)

机构地区：[1]中国医科大学附属第一医院检验科,辽宁沈阳110001

出　　处：《解剖科学进展》2018年第2期170-172,共3页Progress of Anatomical Sciences

基　　金：国家卫计委资助项目(201402018)

摘　　要：目的评价肺组织特异的lncRNA SFTA1P在肺腺癌患者血清中的表达情况及其对肺腺癌的诊断价值。方法收集本院132名肺腺癌患者术前血清标本,同时选取年龄、性别匹配的73名健康体检者作为对照。采用实时定量PCR方法检测血清中lncRNA SFTA1P的表达水平,并采用受试者工作曲线分析其对肺腺癌的诊断价值。结果肺腺癌患者血清中lncRNA SFTA1P的水平显著高于健康对照(P<0.001),ROC曲线下面积为0.627。结论lncRNA SFTA1P是潜在的肺腺癌诊断的血清学标志物。Objective To evaluate the expression level and diagnostic value of lncRNA SFTA1P in serum of lung adenoearcinoma patients. Methods The serum samples of 132 lung adenoearcinoma patients from our hospital were collected, with 73 healthy as controls with comparable sex and age. The serum lncRNA SFTA1P levels were quantified with real time PCR method. The receiver operating characteristic curve was also constructed to analyze its diagnostic value. Results The level of serum lncRNA SFTA1P was higher in lung adenocarcinoma patients than in healthy controls （P〈0.001） , the area under the curve was 0.627. Conclusion lncRNA SFTA1P is a potential serum biomarker for the diagnosis of lung adenocarcinoma.

关 键 词：肺癌 长链非编码RNA SFTA1P 诊断 

分 类 号：R734.2[医药卫生—肿瘤]