ANO1钙激活氯通道生理功能及调节机制概述  

Physiologic fuctions and regulation mechanism of Ano1 Ca^(2+)-activated chloride channel

作　　者：赵玉洁 马可 肖庆桓 ZHAO Yu-jie, MAKe, XIAO Qing-huan(Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, Chin)

机构地区：[1]中国医科大学药学院离子通道药理研究室,沈阳110122

出　　处：《解剖科学进展》2018年第2期201-204,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金(31371145)

摘　　要：Anoctamin 1(ANO1)钙激活氯通道广泛存在于身体各个组织,促进细胞增殖,参与感觉传递,调节血压,促进上皮细胞分泌,促进肿瘤细胞迁移等。ANO1功能异常可导致许多疾病,例如癌症、高血压、胃肠道运动紊乱、囊性纤维化。本文讨论ANO1在心血管、神经系统、消化系统、呼吸系统、泌尿系统发挥的作用,以及钙离子、钙调蛋白、胆固醇、细胞因子等调控ANO1的机制。Anoctamin 1 （ANO1） is a calcium activated chloride channel, widely expressed in various tissues, plays many important cellular functions, such as cell proliferation, regulation of blood pressure, sensory transmission, epithelial cell secretion, and tumor cell migration. ANO1 dysfunction can lead to many diseases, such as cancer, hypertension, gastrointestinal motility disorders, and cystic fibrosis. This review summaries the role of ANO1 in cardiovascular, nervous, digestive, respiratory, and urinary systems, and discuss the mechanisms in which calcium, calmodulin, cholesterol, cytokines regulate ANO1.

关 键 词：钙激活氯通道 调节血压 生理功能 上皮细胞分泌 肿瘤细胞迁移 囊性纤维化 细胞增殖 感觉传递 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]