脑出血后脑水肿的形成机制及药物治疗研究进展  

Mechanism of brain edema after intracerebral hemorrhage and research progress of drug therapy

作　　者：韩鹏[1] 李力仙[1] HAN Peng, LI Lixian(Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin 150001, Chin)

机构地区：[1]哈尔滨医科大学附属第一临床医院神经外科,哈尔滨150001

出　　处：《临床与病理杂志》2018年第2期424-428,共5页Journal of Clinical and Pathological Research

摘　　要：脑水肿是脑出血后必然出现的病理生理过程,是脑出血后最严重的并发症,会导致出血后脑组织的二次脑损伤。同时,因其发生时细胞外液体增加,致使颅内压升高,进而使得神经功能受损,造成严重的不良后果。脑水肿的发病机制较多且复杂,只有根据发病机制及致病因素对症治疗、消除颅内高压才是治疗水肿的可行方法,因此迫切需要开发新的、有效的抗水肿药物。Cerebral edema is an inevitable pathophysiological process after intracerebral hemorrhage. It is the most serious complication after intracerebral hemorrhage and leads to second brain injury in brain tissue after hemorrhage. Cerebral edema has serious adverse consequences. Increased extracellular fluid leads to increased intracranial pressure, resulting in impaired neurological function. The pathogenesis of cerebral edema is more and more complex; only based on pathogenesis and risk factors for symptomatic treatment and elimination of intracranial hypertension are feasible methods to treat edema. It is necessary to develop new and effective anti-edema drugs.

关 键 词：脑出血 脑水肿 病理机制 药物治疗 

分 类 号：R743.34[医药卫生—神经病学与精神病学]