2例胆囊癌肉瘤及肉瘤样癌临床病理分析  

Gallbladder carcinosarcoma and sarcomatoid carcinoma: A clinicopathologic analysis of two cases

作　　者：任亚敏[1] 胡惠敏[1] REN Yamin, HU Huimin(Department of Pathology. Suzhou Xiangcheng People＇s Hospital, Suzhou Jiangsu 215131, Chin)

机构地区：[1]苏州市相城人民医院病理科,江苏苏州215131

出　　处：《临床与病理杂志》2018年第2期456-461,共6页Journal of Clinical and Pathological Research

摘　　要：采用光镜及免疫组织化学(immunohistochemistry,IHC)等方法对2例胆囊癌肉瘤及肉瘤样癌进行临床、病理回顾性分析并综合文献复习。2名患者均因腹部不适入院,胆囊癌肉瘤光镜下可见癌区、软骨肉瘤及未分化梭形细胞肉瘤区,且癌与肉瘤性结构之间未见明显移行过渡,IHC示癌区表达上皮标志,肉瘤区表达间叶标志;胆囊肉瘤样癌光镜下可见癌区及肉瘤样区,二者之间可见移行过渡,IHC癌区表达上皮标志,肉瘤样区同时表达上皮及间叶标志。胆囊癌肉瘤及肉瘤样癌均比较少见,临床诊断困难,明确诊断需要病理广泛仔细取材及IHC检测。The clinical characteristics and the microscopic and immunohistochemical characteristics of two cases with gallbladder carcinosarcoma and sarcomatoid carcinoma were analyzed with a follow-up period. Related literature was reviewed. Two cases were found with abdominal discomfort. Microscopically, gallbladder carcinosarcoma and sarcomatoid carcinoma all showed neoplasm of carcinoma and sarcoma simultaneously coexisted, but no transitional areas were detected between carcinoma and sarcoma of gallbladder carcinosarcoma, its immunohistochemical markers with spindle cell morphology were mesenchymal positivity. Sarcomatoid carcinoma showed that between carcinoma and sarcoma existed transitional areas and its immunohistochemical markers of sarcoma with spindle cell morphology were epithelial and mesenchymal positivity. Gallbladder carcinosarcoma and sarcomatoid carcinoma both are rare tumors with high malignant neoplasm, which could be firmly diagnosed by sufficient sections and immunohistochemistry（IHC）, also needed to be discriminated from each other and others similar diseases.

关 键 词：胆囊 癌肉瘤 肉瘤样癌 病理 诊断 

分 类 号：R735.8[医药卫生—肿瘤]