TLR4基因rs10983755位点单核苷酸多态性与非小细胞肺癌易感性的相关性研究  

Correlative Analysis between SNP rs10983755 in TLR4 Gene and NSCLC Susceptibility

作　　者：张先娇[1] 苗毅[1] 曲书毅 杨城 谢祥军 刘寒强[2] 王水利[1] ZHANG Xian-jiao1,MIAO Yi1,QU Shu-yi2,YANG Cheng2,XIE Xiang-jun2,LIU Han-qiang2,WANG Shui-li1(1 Shaanxi provincial People＇s Hospital, Affiliated Hospital of Xi＇an Medical University, Xi＇an, Shaanxi, 710068, China; 2 School of Public Health, The Fourth, Military Medical University, Xi＇an, Shaanxi, 710032, Chin)

机构地区：[1]陕西省人民医院,西安医学院附属医院,陕西西安710068 [2]第四军医大学军事预防医学院,陕西西安710032

出　　处：《现代生物医学进展》2018年第4期701-704,共4页Progress in Modern Biomedicine

基　　金：陕西省自然科学基金项目(2014JQ4130)

摘　　要：目的:探讨TLR4基因rs10983755 A/G单核苷酸多态性(SNP)与非小细胞肺癌(NSCLC)易感性的相关性。方法:采用病例-对照研究方法纳入160例非小细胞肺癌患者(NSCLC组)和160例健康对照(NC组),利用MassARRAY飞行时间质谱生物芯片系统对TLR4基因rs10983755位点的单核苷酸多态性进行分型检测,并进行统计学分析。结果:rs10983755等位基因频率在中国汉族NSCLC患者和健康人群中的分布差异具有统计学意义(P<0.05),A等位基因携带者NSCLC发生风险是G等位基因携带者的1.821倍(95%CI=1.124~2.906);rs10983755基因型频率在NSCLC患者和健康人群中分布差异具有统计学意义(P<0.05),AA+AG基因型NSCLC发生风险是GG基因型的2.103倍(95%CI=1.118~3.898)。结论:TLR4基因rs10983755 A/G单核苷酸多态性与NSCLC的易感性显著相关,A是风险等位基因。Objective： To investigate the correlation of rs10983755 A/G SNP of TLR4 with non-small cell lung cancer（NSCLC）susceptibility in a population in Shaanxi province. Methods： Based on case-control study, Mass ARRAY platform which based on MALDI-TOF mass spectrometry technology was used to identify the genotypes of rs10983755 of TLR4 gene in 160 cases of NSCLC patients and 160 cases of healthy control in a population in Shaanxi province. Then, we did statistics analysis with epidemiological data and clinical data to find the association of SNP with NSCLC susceptibility. Results： There was a significant difference in the genotypes of the TLR4 SNP rs10983755 between the NSCLC patients and controls（P〈0.05）. NSCLC patients with the A allele showed a significantly higher risk of NSCLC（P〈0.05） compared with the G allele, indicating that the A allele SNP rs10983755 was associated with NSCLC risk（OR=1.821, 95% CI=1.124～2.906）. Compared with GG genotype, AA＋AG genotype was significantly associated with increased risk of NSCLC（OR=2.103, 95% CI=1.118～3.898）. Conclusion： The single nucleotide polymorphism of the rs10983755 of TLR4 gene was correlated with NSCLC susceptibility in a population in Shaanxi province,and the allele A was a risk allele.

关 键 词：TOLL样受体4 单核苷酸多态性 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]