乳腺癌改良根治术联合自体植皮术对乳腺癌的疗效及对患者1～3年复发率的影响  

Effect of radical resection combined with autologous skin grafting on breast cancer and its impact on 1 -3 years recurrence rate

作　　者：韩国晖[1] 白向东[1] 张渤[1] 姜鸿南[2] Han Guohui1, Bai Xiangdong1, Zhang Bo1, Jiang Hongnan2(1Three Wards of Breast Surgery, Shanxi Provincial Tumor Hospital, Taiyuan 030013, China;2Department of Breast Surgery, Second Hospital of Shanxi Medical University,Taiyuan 030001, Chin)

机构地区：[1]山西省肿瘤医院乳腺外科三病区,太原030013 [2]山西医科大学第二医院乳腺外科,太原030001

出　　处：《中国实用医刊》2018年第3期37-40,共4页Chinese Journal of Practical Medicine

摘　　要：目的 研究乳腺癌改良根治术联合自体植皮术对乳腺癌患者的疗效及对患者1～3年复发率的影响.方法 选取90例局部晚期乳腺癌（初诊或新辅助治疗后肿瘤直径≥10 cm）患者,依据随机数字表法分为观察组（45例）和对照组（45例）.对照组给予乳腺癌改良根治术治疗,观察组给予乳腺癌改良根治术联合自体植皮术治疗.观察比较两组疗效、手术时间、术后引流时间、住院时间、并发症及1～3年复发率.结果 对照组与观察组术后引流时间比较差异未见统计学意义（P＞0.05）;观察组手术时间和住院时间均长于对照组（P均＜0.05）;观察组皮瓣中轻度坏死率[2.22％ （1/45）]低于对照组[13.33％ （6/45）],观察组皮瓣总坏死率[4.44％（2/45）]低于对照组[24.44％（8/45）],差异均有统计学意义（P均＜0.05）.随访第1年,观察组复发率低于对照组（P＜0.05）;第2年及第3年随访,两组复发率比较差异均未见统计学意义（P均＞0.05）.结论 乳腺癌改良根治术联合自体植皮术治疗局部晚期乳腺癌,可降低术后并发症的发生率,减少治疗中皮瓣坏死率和复发率,但是延长了患者的住院时间,可供临床借鉴参考.Objective To study the efficacy of modified radical mastectomy combined with autologous skin grafting on patients with breast cancer and the effect on 1-3 years recurrence rate.Methods Ninety patients with breast cancer （tumor diameter ≥ 10 cm after primary treatment or neoadjuvant therapy） were selected and divided into observation group （45 cases） and control group （45 cases） according to random number table method.Patients in control group received modified radical mastectomy of breast cancer,patients in observation group underwent modified radical mastectomy for breast cancer combined with autologous skin grafting.Efficacy,operation time,postoperative drainage time,hospital stay,postoperative complications,the recurrence rate during 1-3 years after treatment were observed and compared between the two groups.Results There was no significant difference in postoperative drainage time between control group and observation group （P 〉 0.05）.The operation time and hospital stay in observation group were significantly longer than those in control group （all P 〈0.05）;the rate of mild and medium necrosis of skin flap in observation group[2.22% （1/45）] was significantly lower than that in control group[13.33 （6/45）],total flap necrosis rate in observation group [4.44% （2/45）] was significantly lower than that in control group[24.44% （8/45）],and the differences were significant between the two groups （both P 〈 0.05）.The follow-up rate was 100%;in the first year after operation,the total incidence of complications in observation group was significantly lower than that in control group （P 〈 0.05）;in the second and third years of follow-up,there was no significant difference in the incidence of complications between the two groups （both P 〉 0.05）.Conclusions Modified radical mastectomy combined with autologous skin grafting in the treatment of locally advanced breast cancer,can reduce the incidence of complications,occurrence of flap necrosis in treatment and the r

关 键 词：乳腺癌改良根治术 自体植皮术 乳腺癌 疗效 复发率 

分 类 号：R737.9[医药卫生—肿瘤]