四磨汤对宫颈癌化疗患者胃肠功能的保护作用及对血清IL-8、CEA、CA125水平的影响  

Protective Effect of Simo Tang on the Gastrointestinal Function of Endostar Combined with Paclitaxel Liposome-treated Cervical Cancer Patients and Effect on the Serum IL-8, CEA, CA125 Levels

作　　者：沈娜 刘黎[1] 刘雪梅 唐仕敏[1] 李源 SHEN Na1, LIU Li1, L1U Xue-mei1, TANG Shi-min1, LI Yuan2(1 Department of oncology, Suining Central Hospital, Suining, Sichuan, 629000, China; 2 Department ofoncology, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan, 646000, Chin)

机构地区：[1]遂宁市中心医院肿瘤科,四川遂宁629000 [2]泸州医学院附属医院肿瘤科,四川泸州646000

出　　处：《现代生物医学进展》2018年第5期935-938,888,共5页Progress in Modern Biomedicine

基　　金：四川省卫生厅科研基金项目(120351)

摘　　要：目的:研究四磨汤对恩度联合力朴素治疗的宫颈癌患者胃肠功能的保护作用及对其血清白细胞介素8(IL-8)、癌胚抗原(CEA)、糖类抗原125(CA125)的影响。方法:选取2015年9月至2016年8月我院收治的88例宫颈癌患者,根据患者入院顺序分为观察组和对照组,每组44例。对照组在放疗基础上加以恩度联合力朴素完成化疗,观察组在对照组治疗基础上加以四磨汤。比较两组患者治疗前后血清IL-8、CEA、CA125水平及外周血CD3^+、CD4^+、CD8^+细胞比例的变化和胃肠道毒副反应、胃肠道放射性损伤的发生情况。结果:治疗后,两组患者血清IL-8、CEA、CA125水平均较治疗前显著降低(P<0.05),且观察组的血清IL-8、CEA、CA125水平较对照组明显降低(P<0.05);两组患者CD3^+、CD4^+细胞比例较治疗前显著降低(P<0.05),CD8^+细胞比例较治疗前显著升高(P<0.05),但观察组的CD3^+、CD4^+、CD8^+细胞比例细胞比例显著高于对照组(P<0.05)。观察组不良反应发生率、早期胃肠道放射性损伤发生率、Ⅱ、Ⅲ级胃肠道放射性损伤率均显著低于对照组(P<0.05)。结论:四磨汤用于恩度联合力朴素治疗的宫颈癌患者能有效保护患者胃肠功能,降低患者血清IL-8、CEA、CA125水平,增强患者免疫力。Objective： To study the protective effect of Simo tang on the gastrointestinal function of endostar combined with paclitaxel liposome-treated cervical cancer patients and effect on the serum interleukin 8 （IL-8）, carcinoembryonic antigen （CEA）, carbohydrate antigen 125 （CA125） levels. Methods： From September 2015 to August 2016, 88 patients with cervical cancer admitted in our hospital were divided into the observation group and the control group according to the order of admission. The control group was treated with endostar combined with paclitaxel liposome on the basis of radiotherapy, the observation group was given simo tang based on the treatment of control group. The serum levels of IL-8, CEA and CA125, the peripheral blood CD3＋, CD4＋, CD8＋ cells, gastrointestinal toxicity and gastrointestinal radioactivity injury in the two groups were compared. Results： After treatment, the serum levels of IL-8, CEA and CA125 in both groups were significantly lower than those before treatment （P〈0.05）. Compared with the control group, the serum levels of IL-8, CEA and CA125 in the observation group were lower （P〈0.05）. After treatment, the ratio of CD3＋,CD4＋ cells in both groups were significantly lower than those before treatment （P〈0.05）, but the CD3＋ and CD4＋ cells in the observation group were significantly higher than those in the control group （P〈0.05）, the ratio of CD8＋ cells in both groups were significantly higher （P〈0. 05）, the ratio ofCD8＋ cells in the observation group was significantly higher than that in the control group （P〈0.05）. The incidence rate of adverse reaction, early gastrointestinal radioactive injury and gastrointestinal tract II and III in the observation group were significantly lower than those of the control group （P〈0.05）. Conclusion： Simo tang combined with paclitaxel liposome can effectively protect the gastrointestinal function, reduce the levels of serum IL-8, CEA and CA125 levels and enhance the immunity of

关 键 词：四磨汤 宫颈癌 胃肠功能 白细胞介素8 癌胚抗原 糖类抗原125 

分 类 号：R737.33[医药卫生—肿瘤] R285.5[医药卫生—临床医学]