角质形成细胞角化分化影响因素的研究进展  

Influencing factors for keratinized differentiation of keratinocytes

作　　者：丁鑫鑫 李雪[1] 王佳 顾芯铭[1] 吴岸谦 周延民[1] Ding Xinxin, Li Xue, Wang Jia,Gu Xinming, Wu Anqian, Zhou Yanmin(Department of Oral Implantology, School of Stomatology, Jilin University, Changchun 130021, Chin)

机构地区：[1]吉林大学口腔医学院种植中心,长春130021

出　　处：《中华口腔医学杂志》2018年第4期284-288,共5页Chinese Journal of Stomatology

基　　金：国家自然科学基金（81570983）;吉林省省级经济结构战略调整引导资金专项（2014G075）;吉林省科技发展计划（20160101138JC）

摘　　要：口腔角化黏膜对维持牙周组织健康有重要作用。角化黏膜缺损增加种植手术及后期修复并发症的风险。目前游离龈移植及结缔组织移植仍是治疗角化龈缺损的金标准，调控非角化黏膜向角化黏膜转化是一种高效且损伤小的方法。角质形成细胞是口腔黏膜的重要组成部分，其最后是否分化成角化黏膜受结缔组织微环境中的多种分子及离子影响，为深入了解角质形成细胞的角化分化过程，本文就影响其角化分化的相关因素及可能机制做一综述。Keratinized mucosa in oral cavity plays an important role in periodontal health. The defect of keratinized mucosa may increase the risks of complication of oral implant surgery and restoration. Graft of keratinized tissue and connective tissue are still the gold standard for treating keratinized mucosa defect now. The current research focus on how to modulate non-keratinized mucosa to highly-efficient and minimally-invasive keratinized mucosa. Keratinocytes are critical components of oral mucosa and its final differentiation into keratinized mucosa is controlled by the connective tissue microenvironment involving a variety of molecules and ions. To fully understand keratinized differentiation of keratinocyte, this review focuses on its influence factors and possible mechanisms under the differentiation.

关 键 词：细胞分化 结缔组织 黏膜 口腔 角质形成细胞 

分 类 号：R781[医药卫生—口腔医学]