丁苯酞注射液对急性脑梗死患者疗效及侧支代偿血管建立的影响  

作　　者：邵淋淋 陈良富 方跃屏 宋水江 

机构地区：[1]浙江省东阳市中医院,322100 [2]浙江大学附属第二医院神经内科,310000

出　　处：《浙江临床医学》2018年第4期616-618,共3页Zhejiang Clinical Medical Journal

摘　　要：目的探究丁苯酞注射液对急性脑梗死患者的临床疗效及对侧支代偿血管建立的影响。方法选取自2015年1月至2016年1月收治的100例急性脑梗死患者，按随机数表分为对照组和观察组，每组各50例。两组患者均给予常规治疗，观察组在此基础上再给予丁苯酞注射液治疗。观察两组患者治疗后的疗效及侧支循环建立情况，检测并比较治疗前后的美国国立卫生研究院卒中量表（NIHSS）评分、Barthel指数（BI）评分、脑血管储备功能指标、侧支循环相关指标。结果观察组治疗后的有效率高于对照组，差异具有统计学意义（P〈0．05）；与治疗前比较，两组患者治疗后的NIHSS评分、脉动指数（PI）值均降低，BI评分、大脑中动脉（MCV）平均流速增加、脑血管储备功能（CVR）（％）、血清血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）、脑源性神经营养因子（BDNF）含量均升高，治疗前后比较差异具有统计学意义（P均〈0．05），治疗后上述指标观察组均优于对照组（p均〈0．05）。观察组侧支循环建立率高于对照组，差异具有统计学意义（P〈0．05）。结论丁苯酞注射液治疗急性脑梗死的疗效显著，不仅能提高脑血管储备能力以改善脑缺血区血供，保护神经功能，还能促进侧支代偿血管的建立以减轻脑梗死症状。Objective To investigate the clinical effect of butylphthalide injection on acute cerebral infarction and its influence on the establishment of collateral blood vessel. Methods 100 cases of patients with acute cerebral infarction were selected from January 2015 to January 2016 in our hospital as the research objects and randomly divided into control group and observation group, 50 cases in each group. After admission, the two groups of patients were given conventional treatment, the observation group on the basis of the treatment of butylphthalide injection. The curative effect of collateral circulation in the two groups of patients were observed after the establishment, before examination and after treatment. The National Institutes of Health Stroke Scale （NIHSS） score, Barthel BI score, cerebral vascular reserve function, collateral circulation related indicators were compared. Results The effective rate in the observation group was higher than that in the control group, the difference was statistically significant （P〈0.05） . The serum levels of vascular endothelial growth factor （VEGF） , basic fibroblast growth factor （bFGF） and brain-derived neurotrophic factor （BDNF） were increased in the two groups. The middle cerebral artery （ MCV ） average flow rate, cerebrovascular reserve （ CVR_ ） % and pulsatility index （ PI ） were all decreased and the BI scores were increased after treatment （ P〈0.05 ） . The difference between the two groups was statistically significant （ P〈0.05 ） . The difference between the two groups after treatment was statistically significant （ P〈0.05 ） .The rate of collateral circulation in the observation group was higher than that in the control group, the difference was statistically significant （P〈0.05） . Conclusion Butylphthalide injection is effective in treating acute cerebral infarction, not only can improve cerebral blood reserve capacity, improve cerebral blood supply collaterals compensatory blood vessels to relieve cerebr

关 键 词：丁苯酞注射液 急性脑梗死 疗效 侧支代偿血管建立 

分 类 号：R743.33[医药卫生—神经病学与精神病学]