病理性近视的发病机制及治疗的研究进展  

Research progress on pathogenesis and treatment of pathologic myopia

作　　者：肖博[1,2,3,4] 王红燕 楚艳华[1,2,3,4] XIAO Bo;WANG Hong-yan;CHU Yan-hua(Department of Vitreous and Retina, Tianjin Eye Hospital, Tianjin 300020, Chin;Tianjin Key Lab of Ophthalmology and Visual Scienc;Tianjin Eye Institut;Clinical College of Ophthalmology, Tianjin Medical Universit)

机构地区：[1]天津市眼科医院玻璃体视网膜科,天津300020 [2]天津市眼科学与视觉科学重点实验室 [3]天津市眼科研究所 [4]天津医科大学眼科临床学院

出　　处：《中国城乡企业卫生》2018年第3期51-54,共4页Chinese Journal of Urban and Rural Enterprise Hygiene

基　　金：天津市应用基础及前沿技术研究计划项目(15JCYBJC26500)

摘　　要：近视在所有眼科疾病中发病率第一,病理性近视(PM)属于近视的一种,其特征是眼轴延长及病理改变如巩膜变薄、后巩膜葡萄肿及各种眼底病变。PM的发病率逐年增高,并有年轻化趋势,越来越多的青壮年罹患PM。PM及其相关并发症常导致视力下降或盲,是导致青壮年人群视力下降最重要的原因之一,不但导致患者生活质量严重下降,也给社会造成巨大经济负担。本文通过对国内外相关文献进行整理分析,对PM的发病机制特别是巩膜主动塑形的机制及目前PM治疗研究前沿特别是核黄素-A波紫外线巩膜交联治疗的研究进展进行综述。Myopia is the most common eye disease among all the eye diseases. Pathologic myopia（PM） is a specific type of myopia,characterized by the elongation of eye axis length and pathological changes such as scleral thinning,posterior staphyloma and various fundus diseases. The incidence of PM has gone up on an annual basis and has a lower-age tendency with more and more young people getting the disease.PM and its complications can often lead to vision loss and blindness which is a major factor causing young people to lose eye sight. PM not only affects the quality of life in its patients but also brings heavy social and economic burden. Based on the arrangement and analysis of correlative foreign and domestic literatures,we review the pathogenesis of PM especially the pathogenesis of scleral active reshaping and the treatment of PM especially the treatment of riboflavin and ultraviolet A scleral crosslinking.

关 键 词：病理性近视 发病机制 巩膜交联 核黄素-A波紫外线 

分 类 号：R77[医药卫生—眼科]