紧密连接蛋白在人宫颈癌组织中的表达及其临床意义  

Expression of Occludin protein in cervical cancer and its clinical significance

作　　者：张彬[1] 陈丽红[1] 邹亦庐[1] 包秋芳 ZHANG Bin, CHEN Li - hong, ZOU Yi - lu, BAO Qiu - fang(Department of Coamecology and Obstetrics, The First Affiliated Hosptial of Fujian Medical University, Fuzhou 350005, Chin)

机构地区：[1]福建医科大学附属第一医院妇产科,福州350005

出　　处：《中国临床药理学杂志》2018年第7期812-814,共3页The Chinese Journal of Clinical Pharmacology

基　　金：福建省自然科学基金资助项目(2017J01282)

摘　　要：目的分析紧密连接蛋白(Occludin)在人宫颈癌中的表达及其临床意义。方法选取40例宫颈癌患者为研究对象,用免疫印迹法检测Occludin蛋白在40对配对宫颈癌组织和正常组织中的表达情况,分析其蛋白表达与临床病理参数的相关性。结果在正常组织和癌组织中Occludin蛋白的低表达率分别为62.50%(25例/40例)和77.50%(31例/40例),高表达率分别为37.50%(15例/40例)和22.50%(9例/40例),Occludin蛋白的表达量分别为(0.39±0.34)和(0.11±0.11),差异均有统计学意义(均P<0.05)。Occludin蛋白表达水平与患者年龄、肿瘤大小、FIGO分期、病理分级、淋巴结转移等均无明显相关性(均P>0.05)。结论宫颈癌组织中Occludin蛋白呈异常低表达,可能参与了宫颈癌的发生与发展病理过程,但与患者临床病理特征无关。Objective To analyze the expression of Occludin in human cervical cancer and its clinical significance. Methods Forty patients with cervical cancer were selected as the research object, and the expres- sion of Occludin in 40 couples of cancer tissue and normal tissue were measured by Western Blotting. The correlation between expression of Occludin protein and clinical characteristics was analyzed. Results In the cancer and normal tissues, the low expression rates of Occludin protein were 62.50% （25 cases / 40 cases） and 77.50% （31 cases / 40 cases） , the high expression rates of Occludin protein were 37.50% （ 15 cases / 40 cases） and 22.50% （9 cases/40 cases） , the expression quantity of Occludin protein were （0.39 ± 0.34） and （0. 11 ± 0. 11 ）, the differences were statistically significant（ all P 〈 0.05 ）. There was no significant correlation between the level of Occludin expression and pa- tients＇ age, tumor size, FIGO stage, pathological grading and lymph node metastasis （ all P 〉 0. 05 ）. Conclusion Down - regulation of Occludin protein was observed in cervical cancer tissues, which may contribute to the development of cervical cancer. However, it was not correlated with the patients＇ clinical characteristics.

关 键 词：紧密连接蛋白 宫颈癌 临床病理特征 

分 类 号：R737.33[医药卫生—肿瘤]