纯红细胞白血病  

Pure erythroid leukemia

作　　者：武焕玲[1] 张炳昌[1] 李元堂[1] 张之芬[1] Wei Wang 

机构地区：[1]山东大学附属省立医院检验医学部,济南250021 [2]美国德克萨斯大学MD Anderson癌症中心

出　　处：《临床血液学杂志》2018年第2期245-248,共4页Journal of Clinical Hematology

摘　　要：在2016年更新的WHO造血与淋巴组织肿瘤分类方案中,以红系增生为主的髓系肿瘤的诊断,原始髓细胞的比值不再以骨髓细胞非红细胞计数（non-erythroid cell count,NEC）,而改为骨髓全部有核细胞计数（all nuclear cell count,ANC）。因此,根据2008年及以前WHO分类标准诊断的急性红白血病（acute erythroid leukemia,AEL）将有很大变化,其中AEL（红/髓亚型）从急性髓系白血病,不能分类（AML,NOS）中去除,The category of acute erythroid leukemia（AEL）was significantly revised in the recent published2016 revision to the World Health Organization（WHO）classification of myeloid leukemia.In previous revision of2008 WHO classification,AEL was classified into two subtypes,acute erythroid/myeloid leukemia and pure erythroid leukemia（PEL）,whereas in the 2016 WHO update,erythroid/myeloid leukemia was merged into MDS and AML,NOS.PEL becomes the only one type of AEL.PEL is a rare and aggressive type of acute leukemia with a lot remaining unknown.In this review,we briefly discuss the main changes in the updated WHO diagnosis criteria of AEL,and focus on the clinical features,diagnosis,potential pathogenesis and molecular biology of PEL.

关 键 词：纯红细胞白血病 诊断 生物学特征 发病机制 

分 类 号：R733.7[医药卫生—肿瘤]