小儿肠道畸形术后肠道动力障碍相关病理研究进展  

Advances of histopathological study on postoperative intestinal dysmotility in pediatric intestinal malformations

作　　者：黄坚鹄 陆薇 蔡威[1] Huang J ianhu;Lu Wei;Cai Wei(Department of Pediatric Surgery, Affiliated Xinhua Hospital, Shanghai J iao Tong University School of Medicine, Shanghai 200092, China（ Huang J H , Cai W;Shanghai Key Laboratory of Pediatric Gastroenterology ＆ Nutrition, Shanghai 200092, China （Lu W)

机构地区：[1]上海交通大学附属新华医院小儿外科,200092 [2]上海市小儿消化与营养重点实验室

出　　处：《中华小儿外科杂志》2018年第3期231-234,F0003,共5页Chinese Journal of Pediatric Surgery

基　　金：上海市小儿消化与营养重点实验室（14DZ2272400）;上海市卫生系统重要疾病联合攻关项目（2013ZYJ130017）;上海市科学技术委员会科研计划项目（14411950400/14411950401）

摘　　要：小儿肠道畸形是常见的需要外科手术介入的疾病，多数肠道畸形患儿能取得良好的手术效果及预后。然而，仍有部分患儿在手术矫正肠道畸形后存在因肠动力障碍导致的肠梗阻症状反复发作，影响患儿的长期预后。而肠道神经、肌肉及Cajal细胞的组织病理学改变可能是导致术后肠道动力障碍的原因所在。本文对目前临床上常见肠道畸形患儿术后出现肠动力障碍的现状进行总结，并对相应的组织病理研究进展进行综述，为小儿肠道畸形术后肠动力障碍的进一步研究提供依据。Pediatric intestinal malformations are common diseases require surgical intervention. The majority of patients with intestinal malformations can achieve good surgical results and prognosis. However, there are still some children with recurrent symptoms of intestinal obstruction due to intestinal dysmotility, affecting children with prolonged prognosis after surgical correction of intestinal malformations. The histopathological changes of enteric nervous system, muscle and interstitial cells of Cajal may be the cause of bowel motility disorder. We summarized the current status of postoperative intestinal dysmotility in some common intestinal malformations, and reviewed the histopathological research, to provide reliable basis for further research.

关 键 词：肠梗阻 先天畸形 组织病理学 

分 类 号：R726.5[医药卫生—儿科]