核酸适配体在肿瘤血清标志物筛选中的应用研究  被引量:3

Study on the application of aptamers in the screening of tumor serum markers

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作  者:马淑玲 曾家豫[1] MA Shuling;ZENG Jiayu(College of Life Science, Northwest Normal University, Lanzhou 730070, P.R.Chin)

机构地区:[1]西北师范大学生命科学学院,兰州730070

出  处:《生物医学工程学杂志》2018年第2期320-323,共4页Journal of Biomedical Engineering

基  金:国家自然科学基金(81360333)

摘  要:肿瘤血清标志物的核酸适配体是利用指数富集的系统进化技术(SELEX),从体外筛选获得的一种能与肿瘤血清标志物高特异性、高亲和性结合的寡核苷酸分子。利用核酸适配体的优势,探寻对肿瘤更具诊断价值的新的肿瘤标志物。目前在肝癌、胃癌等肿瘤的研究中已经取得了一定成果。本文综述了当前核酸适配体及其在肿瘤血清标志物筛选中的相关研究,讨论了肿瘤血清标志物的核酸适配体在肿瘤诊断中的价值以及目前的研究所存在的问题。期望通过本文的综合描述,有助于人们更好地了解肿瘤血清标志物核酸适配体的筛选,并为新的肿瘤血清标志物的发现提供帮助。The nucleic acid adapters of tumor serum markers are oligonucleotide molecules with high specificity and high affinity with tumor serum markers obtained by in vitro screening with systematic evolution of ligands by exponential enrichment (SELEX). Researchers take the advantage of the nucleic acid adapter to explore new tumor serum markers that have more diagnostic value for tumor diagnosis. Recently, some achievements have been achieved in the research of liver cancer and stomach cancer. This paper has reviewed nucleic acid adapter and its research in the serum tumor marker screening, and discussed the value of the nucleic acid adapter of serum tumor markers in the diagnosis, as well as current problems existing in the research. This paper is very useful to help people better understand the screening of nucleic acid adapters of tumor serum markers, and to provide help in discovering new tumor serum markers.

关 键 词:核酸适配体 肿瘤血清标志物 肿瘤诊断 

分 类 号:R730.4[医药卫生—肿瘤]

 

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