腹膜透析致腹膜纤维化的发生机制及其防治的研究进展  

Research Progress on Mechansim of Peritoneal Dialysis Inducing Peritoneal Fibrosis and Its Prevention

作　　者：郭淑婷 唐阁[2] 李维[2] GUO Shuting1 ,TANG Ge2 ,LI Wei1(1. Postgraduate School of Tianjin University of TCM, Tianjin 300193, China ;2. Nephrology Department, The First Affiliated Hospital of Tianjin University of TCM ,Tianjin 300193 ,Chin)

机构地区：[1]天津中医药大学研究生院,天津300193 [2]天津中医药大学第一附属医院肾病科,天津300193

出　　处：《辽宁中医杂志》2018年第3期651-653,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金项目(81503393)

摘　　要：近年来随着终末期肾病（ESRD）发病率的不断攀升,腹膜透析（PD）作为ESRD的主要替代治疗方法之一,因其对残余肾功能的保护、心血管系统的维稳等作用优势,已在临床得到广泛应用。但随着透析龄的增加,腹膜纤维化引起的超滤衰竭等并发症极大程度制约了PD的顺利进行,甚至已成为患者退出PD的主要原因。文章就近年来PD患者腹膜纤维化的发生机制及其防治的研究进展做一综述,以期为未来防治腹膜纤维化的科研和临床实践提供不同的着眼点,最终通过多靶点、多途径的防治方法改善腹膜纤维化并提高腹膜透析患者的生存质量。In recent years,with the increasing incidence of the end-stage renal disease（ ESRD） and because the advantage of the protection of residual renal function and the cardiovascular system stability,peritoneal dialysis（ PD） as one of the main alternative treatments of ESRD has been widely used in clinical treatment. However,with the increase of age of dialysis and ultrafiltration failure,peritoneal fibrosis,one of the most common complication,greatly restricted the PD smoothly,and even has become the main cause of patients withdrew from the PD. In this paper,the progress in the pathogenesis and prevention of peritoneal fibrosis in patients with PD was made a brief,in order to provide different views for future research and clinical practice and finally through the methods of prevention and treatment of multiple targets and pathways to slow the progression of peritoneal fibrosis and improve the living quality of patients with PD.

关 键 词：腹膜透析 腹膜纤维化 作用机制 防治方法 

分 类 号：R57[医药卫生—消化系统]