温阳健脾汤结合艾灸治疗脾胃虚寒型复发性口腔溃疡疗效及对患者血清炎性因子,补体C3,C4水平的影响  

Efficacy of Wenyang Jianpi Decoction Combined with Moxibustion on Spleen and Stomach Cold and Deficiency Recurrent Oral Ulcer and Its Effect on Inflammatory Factor and Complement C3,C4

作　　者：麦熙[1] 王新红[1] 何霞[1] MAI Xi;WANG Xin-hong;HE Xia(Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatological Hospital Affiliated to Guangzhou Medical University, Guangzhou 510140, China)

机构地区：[1]广州医科大学附属口腔医院广州口腔病研究所口腔医学重点实验室

出　　处：《中国实验方剂学杂志》2018年第8期189-193,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省自筹经费类科技计划项目(粤科规财字[2015]110号48)

摘　　要：目的：观察温阳健脾汤结合艾灸治疗复发性口腔溃疡（recurrent oral ulcer,ROU）的疗效,探讨其对患者血清炎性因子,补体C3,C4水平的影响。方法：以广州医科大学附属口腔医院中医科、黏膜科在2015年1月—2016年6月收治的132例ROU患者为研究对象,遵循成组序贯设计法分为治疗组与对照组（各66例）。对照组患者给予复合维生素（Vit）Vit B＋Vit C＋胸腺肽治疗,治疗组在此基础上给予温阳健脾汤结合艾灸治疗,连续治疗10 d,结束后对两组患者疗效,疼痛消失时间与口腔溃疡愈合时间,炎性因子,补体C3,C4水平进行比较。结果：治疗组患者总有效率为95.45%,对照组为84.85%（P〈0.05）;经治疗,治疗组ROU患者疼痛消失时间与口腔溃疡愈合时间明显短于对照组（P〈0.05）;经治疗,治疗组ROU患者血清中白细胞介素-6（interleukin-6,IL-6）水平明显高于对照组,白细胞介素-2（interleukin-2,IL-2）,肿瘤坏死因子（tumor necrosis factor,TNF）-α水平明显低于对照组（P〈0.05）;通过治疗,两组患者血清补体C3,C4水平均明显升高,且治疗组明显高于对照组（P〈0.05）。结论：温阳健脾汤结合艾灸对ROU具有积极的治疗效果,可以显著缩短ROU患者疼痛与愈合时间,上调补体C3,C4水平,抗炎作用明显,值得临床推广应用。Objective： To study the efficacy of Wenyang Jianpi decoction combined with moxibustion and effect on recurrent oral ulcer（ROU） and its effect on inflammatory factor and Complement C3,C4. Method： A total of 132 cases of ROU patients treated in our hospital from January 2015 to June 2016 were selected and divided into two groups according to group sequential design,with 66 cases in each group. Patients in control group were treated with compound vitamin B,vitamin C and thoracic peptide gland; in addition to this therapy,the clinical group was also given Wenyang Jianpi decoction and moxibustion. Then,the treatment effect,the times of pain disappearance and oral ulcer healing,inflammatory factor and Complement C3,C4 were compared. Result： The total effective rate of clinical group was 95. 45%,which was higher than 84. 85% in control group. There was a significant increase（P〈0. 05）. The times of pain disappearance and oral ulcer healing in clinical group were obviously shorter than that in control group（P〈0. 05）. Compared with before treatment,interleukin（IL）-2 and tumor necrosis factor-α（TNF-α） of the two groups after treatment decreased,while IL-6 increased（P〈0. 05）.Compared with control group,the levels of IL-2 and TNF-α in patients of experimental group were lower after treatment,while IL-6 was higher（P〈0. 05）. Compared with before treatment,Complement C3 and C4 of two groups increased after treatment（P〈0. 05）. Compared with control group,the levels in patients of experimental group were higher（P〈0. 05）. Conclusion： Wenyang Jianpi decoction combined with moxibustion was very effective in treating ROU. It can significantly shorten the times of pain disappearance and oral ulcer healing,improve complement C3 and C4,with an apparent anti-inflammation effect,and thus is worthy of clinical promotion and application.

关 键 词：温阳健脾汤 复发性口腔溃疡 脾胃虚寒型 疗效 炎性因子 补体C3 C4 

分 类 号：R22[医药卫生—中医基础理论] R24[医药卫生—中医学]